A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj, Peronne Joseph, Erin Ponting, Yuriy Fedorov, Salendra Singh, Alex Cole, Woncheol Lee, Euisik Yoon, Alessia Baccarini, Peter Scacheri, Ronald Buckanovich, Drew J. Adams, Ronny Drapkin, Brian D. Brown, Analisa DiFeo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

Original languageEnglish
Pages (from-to)122-134
Number of pages13
JournalStem Cell Reports
Volume12
Issue number1
DOIs
StatePublished - 8 Jan 2019

Keywords

  • BET inhibitors
  • miR-181a
  • miRNA sensor
  • ovarian cancer
  • tumor heterogeneity
  • tumor-initiating cells

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