@article{2e378f43297d438b97f1bb48182adfac,
title = "A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs",
abstract = "In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.",
keywords = "BET inhibitors, miR-181a, miRNA sensor, ovarian cancer, tumor heterogeneity, tumor-initiating cells",
author = "{Belur Nagaraj}, Anil and Peronne Joseph and Erin Ponting and Yuriy Fedorov and Salendra Singh and Alex Cole and Woncheol Lee and Euisik Yoon and Alessia Baccarini and Peter Scacheri and Ronald Buckanovich and Adams, {Drew J.} and Ronny Drapkin and Brown, {Brian D.} and Analisa DiFeo",
note = "Funding Information: We thank Norma C. and Albert I. Geller for their constant support of the Gynecological Cancer Translational Research Program at Case Western Reserve University (A.D.). In addition, we thank Dr. Anirban Mitra for the HEYA8 cells, Dr. Goutham Narla for the MDA-MB-231 and H358 cells, and Dr. Steven Presnell for the miR-181a luciferase promoter. We acknowledge the help from Cytometry & Imaging Microscopy Core Facility and the Athymic Animal and Preclinical Therapeutics Core of the Case Comprehensive Cancer Center ( P30CA043703 ). This work was supported by grants from The National Cancer Institute , R01CA197780 (A.D.), Department of Defense , OC150553 (A.D.), and The Young Scientist Foundation (A.D.). Funding Information: We thank Norma C. and Albert I. Geller for their constant support of the Gynecological Cancer Translational Research Program at Case Western Reserve University (A.D.). In addition, we thank Dr. Anirban Mitra for the HEYA8 cells, Dr. Goutham Narla for the MDA-MB-231 and H358 cells, and Dr. Steven Presnell for the miR-181a luciferase promoter. We acknowledge the help from Cytometry & Imaging Microscopy Core Facility and the Athymic Animal and Preclinical Therapeutics Core of the Case Comprehensive Cancer Center (P30CA043703). This work was supported by grants from The National Cancer Institute, R01CA197780 (A.D.), Department of Defense, OC150553 (A.D.), and The Young Scientist Foundation (A.D.). Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2019",
month = jan,
day = "8",
doi = "10.1016/j.stemcr.2018.12.002",
language = "English",
volume = "12",
pages = "122--134",
journal = "Stem Cell Reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "1",
}