A mild, rapid synthesis of freebase [11C]nicotine from [11C]methyl triflate

Youwen Xu, Sung Won Kim, Dohyun Kim, David Alexoff, Michael J. Schueller, Joanna S. Fowler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A rapid, mild radiosynthesis of freebase [11C]nicotine was developed by the methylation of freebase nornicotine with [11C]methyl triflate in acetone (5 min, 45 °C). A basic (pH 10.5–11.0) HPLC system reproducibly yielded freebase [11C]nicotine as a well-defined single peak. The freebase [11C]nicotine was concentrated by solid phase extraction and formulated in 50 µL ethanol (370 MBq/50 µL) without evaporative loss suitable for a cigarette spiking study. A radiochemical yield of 60.4±4.7% (n=3), radiochemical purity ≥99.9% and specific activity of 648 GBq/µmol at EOB for 5 min beams were achieved.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalApplied Radiation and Isotopes
StatePublished - 1 Dec 2016
Externally publishedYes


  • Freebase [C]nicotine
  • [C]methyl triflate


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