@article{6342db80753b412290800f19078c4ef6,
title = "A microRNA polycistron as a potential human oncogene",
abstract = "To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.",
author = "Lin He and Thomson, {J. Michael} and Hemann, {Michael T.} and Eva Hernando-Monge and David Mu and Summer Goodson and Scott Powers and Carlos Cordon-Cardo and Lowe, {Scott W.} and Hannon, {Gregory J.} and Hammond, {Scott M.}",
note = "Funding Information: Acknowledgements We thank members of the Hannon, Lowe and Hammond laboratories for discussions and input. We also thank Z. Xuan, N. Chen, N. Sheth and R. Sachidanandam for bioniformatic analysis. C. Perou and J. Leib provided advice and support for microarray methodologies, and A. Barnes and B. Boone gave assistance with mouse tissue procurement. We are grateful to H. Wendel, C. Scott, C. Marsden and C. Rosenthal, R. Karni, P. Moody and R. Whitaker, who provided advice and technical support. F. Slack coined the oncomiR nomenclature. L.H. and M.T.H. are Fellows of the Helen Hay Whitney Foundation. S.W.L. and C.C.-C. are supported by a program project grant from the NCI. G.J.H is supported by an Innovator Award from the US Army Breast Cancer Research Program and by grants from the DOD and NIH. S.M.H. is a General Motors Cancer Research Foundation Scholar, and J.M.T is a Frederick Gardner Cottrell Postdoctoral Fellow.",
year = "2005",
month = jun,
day = "9",
doi = "10.1038/nature03552",
language = "English",
volume = "435",
pages = "828--833",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Research",
number = "7043",
}