TY - JOUR
T1 - A method to detect progression of glaucoma using the multifocal visual evoked potential technique
AU - Wangsupadilok, Boonchai
AU - Greenstein, Vivienne C.
AU - Kanadani, Fabio N.
AU - Grippo, Tomas M.
AU - Liebmann, Jeffrey M.
AU - Ritch, Robert
AU - Hood, Donald C.
N1 - Funding Information:
Acknowledgments The authors gratefully acknowledge Dr Vorapong Chowchuvech for assistance in statistical analysis. Supported in part by NIH/NEI grant EY02115, the Steven and Shelley Einhorn Research Fund of the New York Glaucoma Research Institute, the Starr Foundation and unrestricted grants from Research to Prevent Blindness to the Department of Ophthalmology, Columbia University, and the Department of Ophthalmology, New York University School of Medicine, New York, NY. The authors had no financial relationship with the organizations that supported this study and instruments that were mentioned in this study.
PY - 2009
Y1 - 2009
N2 - Purpose: To describe a method for monitoring progression of glaucoma using the multifocal visual evoked potential (mfVEP) technique. Methods: Eighty-seven patients diagnosed with open-angle glaucoma were divided into two groups. Group I, comprised 43 patients who had a repeat mfVEP test within 50 days (mean 0.9 ± 0.5 months), and group II, 44 patients who had a repeat test after at least 6 months (mean 20.7 ± 9.7 months). Monocular mfVEPs were obtained using a 60-sector pattern reversal dartboard display. Monocular and interocular analyses were performed. Data from the two visits were compared. The total number of abnormal test points with P < 5% within the visual field (total scores) and number of abnormal test points within a cluster (cluster size) were calculated. Data for group I provided a measure of test - retest variability independent of disease progression. Data for group II provided a possible measure of progression. Results: The difference in the total scores for group II between visit 1 and visit 2 for the interocular and monocular comparison was significant (P < 0.05) as was the difference in cluster size for the interocular comparison (P < 0.05). Group I did not show a significant change in either total score or cluster size. Conclusion: The change in the total score and cluster size over time provides a possible method for assessing progression of glaucoma with the mfVEP technique.
AB - Purpose: To describe a method for monitoring progression of glaucoma using the multifocal visual evoked potential (mfVEP) technique. Methods: Eighty-seven patients diagnosed with open-angle glaucoma were divided into two groups. Group I, comprised 43 patients who had a repeat mfVEP test within 50 days (mean 0.9 ± 0.5 months), and group II, 44 patients who had a repeat test after at least 6 months (mean 20.7 ± 9.7 months). Monocular mfVEPs were obtained using a 60-sector pattern reversal dartboard display. Monocular and interocular analyses were performed. Data from the two visits were compared. The total number of abnormal test points with P < 5% within the visual field (total scores) and number of abnormal test points within a cluster (cluster size) were calculated. Data for group I provided a measure of test - retest variability independent of disease progression. Data for group II provided a possible measure of progression. Results: The difference in the total scores for group II between visit 1 and visit 2 for the interocular and monocular comparison was significant (P < 0.05) as was the difference in cluster size for the interocular comparison (P < 0.05). Group I did not show a significant change in either total score or cluster size. Conclusion: The change in the total score and cluster size over time provides a possible method for assessing progression of glaucoma with the mfVEP technique.
KW - Multifocal visual evoked potentials
KW - Repeat reliability
KW - Visual field progression
UR - https://www.scopus.com/pages/publications/61849183734
U2 - 10.1007/s10633-008-9149-2
DO - 10.1007/s10633-008-9149-2
M3 - Article
C2 - 18830654
AN - SCOPUS:61849183734
SN - 0012-4486
VL - 118
SP - 139
EP - 150
JO - Documenta Ophthalmologica
JF - Documenta Ophthalmologica
IS - 2
ER -