TY - JOUR
T1 - A meta-analysis of dexamethasone use with tonsillectomy
AU - Goldman, Andrew C.
AU - Govindaraj, Satish
AU - Rosenfeld, Richard M.
PY - 2000
Y1 - 2000
N2 - OBJECTIVE: To determine the quantitative impact of intravenous dexamethasone on recovery after tonsillectomy using established principles for metaanalysis. STUDY DESIGN/SETTING: Double-blind randomized-Control trials in which subjects were treated identically except for the presence or absence of perioperative intravenous dexamethasone. Six articles met inclusion criteria. Two investigators extracted data regarding postoperative emesis and return to a soft/regular diet. RESULTS: Pooled analysis using a random effects model revealed a 27% decrease (P < 0.00001) in postoperative emesis attributable to dexamethasone (95% Cl, 12% to 42%). Dexamethosone in-Creased the tolerance of a soft/regular diet at 24 hours by 22% (P < 0.001), but studies were her' erogenous with low precision (95% Cl, 1% to 44%). CONCLUSION: To prevent emesis in 1 child after tonsillectomy, approximately 4 children must receive perioperative dexamethasone. An additional benefit is earlier tolerance of a soft/regular diet, but low precision and heterogeneity among studies preclude definitive conclusions. SIGNIFICANCE: Perioperative dexamethasone administration had a positive impact on recovery from tonsillectomy.
AB - OBJECTIVE: To determine the quantitative impact of intravenous dexamethasone on recovery after tonsillectomy using established principles for metaanalysis. STUDY DESIGN/SETTING: Double-blind randomized-Control trials in which subjects were treated identically except for the presence or absence of perioperative intravenous dexamethasone. Six articles met inclusion criteria. Two investigators extracted data regarding postoperative emesis and return to a soft/regular diet. RESULTS: Pooled analysis using a random effects model revealed a 27% decrease (P < 0.00001) in postoperative emesis attributable to dexamethasone (95% Cl, 12% to 42%). Dexamethosone in-Creased the tolerance of a soft/regular diet at 24 hours by 22% (P < 0.001), but studies were her' erogenous with low precision (95% Cl, 1% to 44%). CONCLUSION: To prevent emesis in 1 child after tonsillectomy, approximately 4 children must receive perioperative dexamethasone. An additional benefit is earlier tolerance of a soft/regular diet, but low precision and heterogeneity among studies preclude definitive conclusions. SIGNIFICANCE: Perioperative dexamethasone administration had a positive impact on recovery from tonsillectomy.
UR - https://www.scopus.com/pages/publications/0033664251
U2 - 10.1067/mhn.2000.111354
DO - 10.1067/mhn.2000.111354
M3 - Article
AN - SCOPUS:0033664251
SN - 0194-5998
VL - 123
SP - 682
EP - 686
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 6
ER -