TY - JOUR
T1 - A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1
T2 - Overall results and dose-risk relation
AU - Tramacere, Irene
AU - Negri, Eva
AU - Bagnardi, Vincenzo
AU - Garavello, Werner
AU - Rota, Matteo
AU - Scotti, Lorenza
AU - Islami, Farhad
AU - Corrao, Giovanni
AU - Boffetta, Paolo
AU - La Vecchia, Carlo
N1 - Funding Information:
This work was conducted with the contribution of the Italian Association for Cancer Research (AIRC). Irene Tramacere was supported by a fellowship from the Italian Foundation for Cancer Research (FIRC). The authors thank Ms. I. Garimoldi for editorial assistance.
PY - 2010/7
Y1 - 2010/7
N2 - Alcohol consumption, together with tobacco, is the best recognised risk factor for oral and pharyngeal cancers (OPC), but several important aspects of this association need to be further explored. In order to provide up to date and more precise quantification of the association between alcohol drinking and OPC risk, we conducted a meta-analysis of available data. We performed a PubMed search of articles published up to September 2009, and we identified 43 case-control and two cohort studies presenting results for at least three categories of alcohol drinking, including a total of 17,085 OPC cases. We derived meta-analytic summary estimates using random-effects models, and taking into account correlation between estimates. We also performed a dose-risk analysis using non-linear random-effects meta-regression models. The pooled relative risk (RR) was 1.21 (95% confidence interval, CI, 1.10-1.33) for ≤1 drink per day, and rose to 5.24 (95% CI, 4.36-6.30) for heavy alcohol drinking (≥4 drinks per day). The dose-risk analysis resulted in RR of 1.29 for 10 g ethanol/day, 3.24 for 50 g ethanol/day, 8.61 for 100 g ethanol/day, and 13.02 for 125 g ethanol/day. This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers. It also indicates an increased risk for moderate doses, i.e., ≤1 drink or 10 g ethanol/day.
AB - Alcohol consumption, together with tobacco, is the best recognised risk factor for oral and pharyngeal cancers (OPC), but several important aspects of this association need to be further explored. In order to provide up to date and more precise quantification of the association between alcohol drinking and OPC risk, we conducted a meta-analysis of available data. We performed a PubMed search of articles published up to September 2009, and we identified 43 case-control and two cohort studies presenting results for at least three categories of alcohol drinking, including a total of 17,085 OPC cases. We derived meta-analytic summary estimates using random-effects models, and taking into account correlation between estimates. We also performed a dose-risk analysis using non-linear random-effects meta-regression models. The pooled relative risk (RR) was 1.21 (95% confidence interval, CI, 1.10-1.33) for ≤1 drink per day, and rose to 5.24 (95% CI, 4.36-6.30) for heavy alcohol drinking (≥4 drinks per day). The dose-risk analysis resulted in RR of 1.29 for 10 g ethanol/day, 3.24 for 50 g ethanol/day, 8.61 for 100 g ethanol/day, and 13.02 for 125 g ethanol/day. This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers. It also indicates an increased risk for moderate doses, i.e., ≤1 drink or 10 g ethanol/day.
KW - Alcohol drinking
KW - Dose-risk relation
KW - Meta-analysis
KW - Oral and pharyngeal caner
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=77953358249&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2010.03.024
DO - 10.1016/j.oraloncology.2010.03.024
M3 - Article
C2 - 20444641
AN - SCOPUS:77953358249
SN - 1368-8375
VL - 46
SP - 497
EP - 503
JO - Oral Oncology
JF - Oral Oncology
IS - 7
ER -