A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

Ivan Stamenkovic, Martine Amiot, John M. Pesando, Brian Seed

Research output: Contribution to journalArticlepeer-review

563 Scopus citations

Abstract

Monoclonal antibodies in the Hermes family recognize a lymphocyte structure that participates in lymphocyte adhesion to endothelium and has been suggested to be the human homolog of the murine Mel-14 lymph node homing receptor. Recently, antibodies against the Hermes antigen, the polymorphic glycoprotein Pgp-1 antigen, and the broadly expressed CDw44 antigen have been shown to recognize the same structure. In this work, cDNA clones encoding the CDw44 antigen were isolated and expressed in COS cells. Two forms were identified: a lymphoid form expressed in hematopoietic cells, and an epithelial form weakly expressed in normal epithelium but highly expressed in carcinomas. The extracellular domain of CDw44 bears homology to cartilage link proteins and a related segment of proteoglycan core protein. However, comparison with the recently identified sequence of the Mel-14 antigen shows that CDw44 and Mel-14 are unrelated.

Original languageEnglish
Pages (from-to)1057-1062
Number of pages6
JournalCell
Volume56
Issue number6
DOIs
StatePublished - 24 Mar 1989
Externally publishedYes

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