A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Liuliu Yang; Yuling Han; Benjamin E. Nilsson-Payant; Vikas Gupta; Pengfei Wang; Xiaohua Duan; Xuming Tang; Jiajun Zhu; Zeping Zhao; Fabrice Jaffré; Tuo Zhang; Tae Wan Kim; Oliver Harschnitz; David Redmond; Sean Houghton; Chengyang Liu; Ali Naji; Gabriele Ciceri; Sudha Guttikonda; Yaron Bram; Duc Huy T. Nguyen; Michele Cioffi; Vasuretha Chandar; Daisy A. Hoagland; Yaoxing Huang; Jenny Xiang; Hui Wang; David Lyden; Alain Borczuk; Huanhuan Joyce Chen; Lorenz Studer; Fong Cheng Pan; David D. Ho; Benjamin R. tenOever; Todd Evans; Robert E. Schwartz; Shuibing Chen

doi:10.1016/j.stem.2020.06.015

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Liuliu Yang
, Yuling Han
, Benjamin E. Nilsson-Payant
, Vikas Gupta
, Pengfei Wang
, Xiaohua Duan
, Xuming Tang
, Jiajun Zhu
, Zeping Zhao
, Fabrice Jaffré
, Tuo Zhang
, Tae Wan Kim
, Oliver Harschnitz
, David Redmond
, Sean Houghton
, Chengyang Liu
, Ali Naji
, Gabriele Ciceri
, Sudha Guttikonda
, Yaron Bram

Duc Huy T. Nguyen, Michele Cioffi, Vasuretha Chandar, Daisy A. Hoagland, Yaoxing Huang, Jenny Xiang, Hui Wang, David Lyden, Alain Borczuk, Huanhuan Joyce Chen, Lorenz Studer, Fong Cheng Pan, David D. Ho, Benjamin R. tenOever, Todd Evans, Robert E. Schwartz, Shuibing Chen

Research output: Contribution to journal › Article › peer-review

550 Scopus citations

Abstract

Yang et al. show that hPSC-derived cells and organoids provide valuable models to study SARS-CoV-2 tropism and to model COVID-19. They find that hPSC-derived pancreatic endocrine cells and human adult hepatocyte and cholangiocyte organoids are permissive to SARS-CoV-2 infection.

Original language	English
Pages (from-to)	125-136.e7
Journal	Cell Stem Cell
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2020.06.015
State	Published - 2 Jul 2020

Keywords

SARS-CoV-2
alpha cells
beta cells
human pluripotent stem cells
liver organoids
pancreatic endocrine cells

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10.1016/j.stem.2020.06.015

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Yang, L., Han, Y., Nilsson-Payant, B. E., Gupta, V., Wang, P., Duan, X., Tang, X., Zhu, J., Zhao, Z., Jaffré, F., Zhang, T., Kim, T. W., Harschnitz, O., Redmond, D., Houghton, S., Liu, C., Naji, A., Ciceri, G., Guttikonda, S., ... Chen, S. (2020). A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell, 27(1), 125-136.e7. https://doi.org/10.1016/j.stem.2020.06.015

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title = "A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids",

abstract = "Yang et al. show that hPSC-derived cells and organoids provide valuable models to study SARS-CoV-2 tropism and to model COVID-19. They find that hPSC-derived pancreatic endocrine cells and human adult hepatocyte and cholangiocyte organoids are permissive to SARS-CoV-2 infection.",

keywords = "SARS-CoV-2, alpha cells, beta cells, human pluripotent stem cells, liver organoids, pancreatic endocrine cells",

author = "Liuliu Yang and Yuling Han and Nilsson-Payant, \{Benjamin E.\} and Vikas Gupta and Pengfei Wang and Xiaohua Duan and Xuming Tang and Jiajun Zhu and Zeping Zhao and Fabrice Jaffr{\'e} and Tuo Zhang and Kim, \{Tae Wan\} and Oliver Harschnitz and David Redmond and Sean Houghton and Chengyang Liu and Ali Naji and Gabriele Ciceri and Sudha Guttikonda and Yaron Bram and Nguyen, \{Duc Huy T.\} and Michele Cioffi and Vasuretha Chandar and Hoagland, \{Daisy A.\} and Yaoxing Huang and Jenny Xiang and Hui Wang and David Lyden and Alain Borczuk and Chen, \{Huanhuan Joyce\} and Lorenz Studer and Pan, \{Fong Cheng\} and Ho, \{David D.\} and tenOever, \{Benjamin R.\} and Todd Evans and Schwartz, \{Robert E.\} and Shuibing Chen",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

day = "2",

doi = "10.1016/j.stem.2020.06.015",

language = "English",

volume = "27",

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journal = "Cell Stem Cell",

issn = "1934-5909",

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Yang, L, Han, Y, Nilsson-Payant, BE, Gupta, V, Wang, P, Duan, X, Tang, X, Zhu, J, Zhao, Z, Jaffré, F, Zhang, T, Kim, TW, Harschnitz, O, Redmond, D, Houghton, S, Liu, C, Naji, A, Ciceri, G, Guttikonda, S, Bram, Y, Nguyen, DHT, Cioffi, M, Chandar, V, Hoagland, DA, Huang, Y, Xiang, J, Wang, H, Lyden, D, Borczuk, A, Chen, HJ, Studer, L, Pan, FC, Ho, DD, tenOever, BR, Evans, T, Schwartz, RE & Chen, S 2020, 'A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids', Cell Stem Cell, vol. 27, no. 1, pp. 125-136.e7. https://doi.org/10.1016/j.stem.2020.06.015

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T1 - A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

AU - Yang, Liuliu

AU - Han, Yuling

AU - Nilsson-Payant, Benjamin E.

AU - Gupta, Vikas

AU - Wang, Pengfei

AU - Duan, Xiaohua

AU - Tang, Xuming

AU - Zhu, Jiajun

AU - Zhao, Zeping

AU - Jaffré, Fabrice

AU - Zhang, Tuo

AU - Kim, Tae Wan

AU - Harschnitz, Oliver

AU - Redmond, David

AU - Houghton, Sean

AU - Liu, Chengyang

AU - Naji, Ali

AU - Ciceri, Gabriele

AU - Guttikonda, Sudha

AU - Bram, Yaron

AU - Nguyen, Duc Huy T.

AU - Cioffi, Michele

AU - Chandar, Vasuretha

AU - Hoagland, Daisy A.

AU - Huang, Yaoxing

AU - Xiang, Jenny

AU - Wang, Hui

AU - Lyden, David

AU - Borczuk, Alain

AU - Chen, Huanhuan Joyce

AU - Studer, Lorenz

AU - Pan, Fong Cheng

AU - Ho, David D.

AU - tenOever, Benjamin R.

AU - Evans, Todd

AU - Schwartz, Robert E.

AU - Chen, Shuibing

PY - 2020/7/2

Y1 - 2020/7/2

N2 - Yang et al. show that hPSC-derived cells and organoids provide valuable models to study SARS-CoV-2 tropism and to model COVID-19. They find that hPSC-derived pancreatic endocrine cells and human adult hepatocyte and cholangiocyte organoids are permissive to SARS-CoV-2 infection.

AB - Yang et al. show that hPSC-derived cells and organoids provide valuable models to study SARS-CoV-2 tropism and to model COVID-19. They find that hPSC-derived pancreatic endocrine cells and human adult hepatocyte and cholangiocyte organoids are permissive to SARS-CoV-2 infection.

KW - SARS-CoV-2

KW - alpha cells

KW - beta cells

KW - human pluripotent stem cells

KW - liver organoids

KW - pancreatic endocrine cells

UR - https://www.scopus.com/pages/publications/85086786731

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DO - 10.1016/j.stem.2020.06.015

M3 - Article

C2 - 32579880

AN - SCOPUS:85086786731

SN - 1934-5909

VL - 27

SP - 125-136.e7

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 1

ER -

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Abstract

Keywords

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