TY - JOUR
T1 - A human kidney cDNA which induces a cell surface protein epitope recognized by a monoclonal antibody against galactosylceramide
AU - Gama Sosa, Miguel A.
AU - De Gasperi, Rita
AU - Battistini, Stefania
AU - Gorman, Mark P.
AU - Kolodny, Robin
AU - Kolodny, Edwin H.
N1 - Funding Information:
This work was supported in part by Grant NIH-NIAID 5P30AI27742-05. R.D.G. was the recipient of the H. I. Duggan Investigator Award from the Arthritis Foundation.
PY - 1996/10/14
Y1 - 1996/10/14
N2 - Antibodies against the myelin glycolipid galactosylceramide are widely used to study the distribution and function of this molecule. However, anti-galactosylceramide antibodies are not monospecific and have been shown to recognize epitopes carried not only by other glycolipids, but also by proteins, Using expression cloning we have identified a human kidney cDNA which induces a cell-surface protein recognized by the anti-galactosylceramide monoclonal antibody R-mab. These findings further support the idea that cross-reactive proteins may mediate some of the biological effects of the anti-galactosylceramide antibodies.
AB - Antibodies against the myelin glycolipid galactosylceramide are widely used to study the distribution and function of this molecule. However, anti-galactosylceramide antibodies are not monospecific and have been shown to recognize epitopes carried not only by other glycolipids, but also by proteins, Using expression cloning we have identified a human kidney cDNA which induces a cell-surface protein recognized by the anti-galactosylceramide monoclonal antibody R-mab. These findings further support the idea that cross-reactive proteins may mediate some of the biological effects of the anti-galactosylceramide antibodies.
UR - https://www.scopus.com/pages/publications/0030583551
U2 - 10.1006/bbrc.1996.1557
DO - 10.1006/bbrc.1996.1557
M3 - Article
C2 - 8878564
AN - SCOPUS:0030583551
SN - 0006-291X
VL - 227
SP - 636
EP - 641
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -