Abstract
The histological fate of an injectable form of type I bovine dermal collagen (Zyderm collagen implant) in the human dermis and subcutaneous tissue has been studied. Sequential biopsies were analyzed by hematoxylin-eosin and Weigert's stains, by immunofluorescence (using a highly specific rabbit anti-Zyderm collagen antibody and a specific anti-human type III collagen antibody), and by electron microscopy. The results of this study suggest that the bovine implant material stimulates a host response resulting in implant degradation and replacement by newly generated host collagen.
| Original language | English |
|---|---|
| Pages (from-to) | 515-522 |
| Number of pages | 8 |
| Journal | Annals of Plastic Surgery |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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