TY - JOUR
T1 - A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
AU - Imai, Masaki
AU - Watanabe, Tokiko
AU - Kiso, Maki
AU - Nakajima, Noriko
AU - Yamayoshi, Seiya
AU - Iwatsuki-Horimoto, Kiyoko
AU - Hatta, Masato
AU - Yamada, Shinya
AU - Ito, Mutsumi
AU - Sakai-Tagawa, Yuko
AU - Shirakura, Masayuki
AU - Takashita, Emi
AU - Fujisaki, Seiichiro
AU - McBride, Ryan
AU - Thompson, Andrew J.
AU - Takahashi, Kenta
AU - Maemura, Tadashi
AU - Mitake, Hiromichi
AU - Chiba, Shiho
AU - Zhong, Gongxun
AU - Fan, Shufang
AU - Oishi, Kohei
AU - Yasuhara, Atsuhiro
AU - Takada, Kosuke
AU - Nakao, Tomomi
AU - Fukuyama, Satoshi
AU - Yamashita, Makoto
AU - Lopes, Tiago J.S.
AU - Neumann, Gabriele
AU - Odagiri, Takato
AU - Watanabe, Shinji
AU - Shu, Yuelong
AU - Paulson, James C.
AU - Hasegawa, Hideki
AU - Kawaoka, Yoshihiro
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/11/8
Y1 - 2017/11/8
N2 - Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate. The highly pathogenic H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exception of the neuraminidase inhibitor-resistant virus, which showed mild-to-moderate attenuation. All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals. Neuraminidase inhibitors showed limited effectiveness against these viruses in vivo, but the viruses were susceptible to a polymerase inhibitor. These results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored. Highly pathogenic avian influenza (HPAI) H7N9 viruses have emerged and raised concerns of a pandemic. Imai et al. characterized an HPAI H7N9 virus isolated from a human. This virus transmitted among ferrets without prior adaptation and caused lethal infection in animals, demonstrating its pandemic potential and the need for surveillance.
AB - Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate. The highly pathogenic H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exception of the neuraminidase inhibitor-resistant virus, which showed mild-to-moderate attenuation. All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals. Neuraminidase inhibitors showed limited effectiveness against these viruses in vivo, but the viruses were susceptible to a polymerase inhibitor. These results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored. Highly pathogenic avian influenza (HPAI) H7N9 viruses have emerged and raised concerns of a pandemic. Imai et al. characterized an HPAI H7N9 virus isolated from a human. This virus transmitted among ferrets without prior adaptation and caused lethal infection in animals, demonstrating its pandemic potential and the need for surveillance.
KW - antiviral sensitivity
KW - ferrets
KW - highly pathogenic avian influenza H7N9 viruses
KW - mice
KW - nonhuman primates
KW - pathogenicity
KW - receptor-binding specificity
KW - replication capacity
KW - transmissibility
UR - http://www.scopus.com/inward/record.url?scp=85031791832&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2017.09.008
DO - 10.1016/j.chom.2017.09.008
M3 - Article
C2 - 29056430
AN - SCOPUS:85031791832
SN - 1931-3128
VL - 22
SP - 615-626.e8
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -