A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane

Stacey M. Frumm; Shengyang Kevin Yu; Joseph Chang; Jordan A. Artichoker; Sonia M. Scaria; Katharine P. Lee; Lauren E. Byrnes; Julie B. Sneddon; Aaron D. Tward

doi:10.1016/j.stem.2020.10.006

A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane

Stacey M. Frumm, Shengyang Kevin Yu, Joseph Chang, Jordan A. Artichoker, Sonia M. Scaria, Katharine P. Lee, Lauren E. Byrnes, Julie B. Sneddon, Aaron D. Tward

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Frumm et al. show that the tympanic membrane (TM) epidermis has distinct stem cell and committed progenitor regions. In homeostasis, keratinocytes migrate across the TM to maintain a thin vibratory surface, and they proliferate only when in proximity to supporting mesenchyme.

Original language	English
Pages (from-to)	315-330.e5
Journal	Cell Stem Cell
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2020.10.006
State	Published - 4 Feb 2021
Externally published	Yes

Keywords

committed progenitor
epidermis
keratinocyte
malleus
migration
stem cell
tympanic membrane

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10.1016/j.stem.2020.10.006

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title = "A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane",

abstract = "Frumm et al. show that the tympanic membrane (TM) epidermis has distinct stem cell and committed progenitor regions. In homeostasis, keratinocytes migrate across the TM to maintain a thin vibratory surface, and they proliferate only when in proximity to supporting mesenchyme.",

keywords = "committed progenitor, epidermis, keratinocyte, malleus, migration, stem cell, tympanic membrane",

author = "Frumm, {Stacey M.} and Yu, {Shengyang Kevin} and Joseph Chang and Artichoker, {Jordan A.} and Scaria, {Sonia M.} and Lee, {Katharine P.} and Byrnes, {Lauren E.} and Sneddon, {Julie B.} and Tward, {Aaron D.}",

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AU - Frumm, Stacey M.

AU - Yu, Shengyang Kevin

AU - Chang, Joseph

AU - Artichoker, Jordan A.

AU - Scaria, Sonia M.

AU - Lee, Katharine P.

AU - Byrnes, Lauren E.

AU - Sneddon, Julie B.

AU - Tward, Aaron D.

PY - 2021/2/4

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N2 - Frumm et al. show that the tympanic membrane (TM) epidermis has distinct stem cell and committed progenitor regions. In homeostasis, keratinocytes migrate across the TM to maintain a thin vibratory surface, and they proliferate only when in proximity to supporting mesenchyme.

AB - Frumm et al. show that the tympanic membrane (TM) epidermis has distinct stem cell and committed progenitor regions. In homeostasis, keratinocytes migrate across the TM to maintain a thin vibratory surface, and they proliferate only when in proximity to supporting mesenchyme.

KW - committed progenitor

KW - epidermis

KW - keratinocyte

KW - malleus

KW - migration

KW - stem cell

KW - tympanic membrane

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ER -

A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane

Abstract

Keywords

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