A glimpse into the structure and function of atypical Type I chaperonins

Mohammed Y. Ansari, Shekhar C. Mande

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might lead chaperonins to perform alternate functions.

Original languageEnglish
Article number31
JournalFrontiers in Molecular Biosciences
Issue numberAPR
StatePublished - 11 Apr 2018
Externally publishedYes


  • Gene duplication
  • GroEL
  • GroES
  • Mycobacterium tuberculosis
  • Protein folding
  • Type I chaperonins


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