A genomic and functional inventory of deubiquitinating enzymes

Sebastian M.B. Nijman, Mark P.A. Luna-Vargas, Arno Velds, Thijn R. Brummelkamp, Annette M.G. Dirac, Titia K. Sixma, René Bernards

Research output: Contribution to journalReview articlepeer-review

1395 Scopus citations


Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important but are less well understood. Here, we present an inventory of the deubiquitinating enzymes encoded in the human genome. In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity.

Original languageEnglish
Pages (from-to)773-786
Number of pages14
Issue number5
StatePublished - 2 Dec 2005
Externally publishedYes


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