A Genomewide Screen of 345 Families for Autism-Susceptibility Loci

Amanda L. Yonan, Maricela Alarcón, Rong Cheng, Patrik K.E. Magnusson, Sarah J. Spence, Abraham A. Palmer, Adina Grunn, Suh Hang Hank Juo, Joseph D. Terwilliger, Jianjun Liu, Rita M. Cantor, Daniel H. Geschwind, T. Conrad Gilliam

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233 Scopus citations

Abstract

We previously reported a genomewide scan to identify autism-susceptibility loci in 110 multiplex families, showing suggestive evidence (P < .01) for linkage to autism-spectrum disorders (ASD) on chromosomes 5, 8, 16, 19, and X and showing nominal evidence (P < .05) on several additional chromosomes (2, 3, 4, 10, 11, 12, 15, 18, and 20). In this follow-up analysis we have increased the sample size threefold, while holding the study design constant, so that we now report 345 multiplex families, each with at least two siblings affected with autism or ASD phenotype. Along with 235 new multiplex families, 73 new microsatellite markers were also added in 10 regions, thereby increasing the marker density at these strategic locations from 10 cM to ∼2 cM and bringing the total number of markers to 408 over the entire genome. Multipoint maximum LOD scores (MLS) obtained from affected-sib-pair analysis of all 345 families yielded suggestive evidence for linkage on chromosomes 17, 5, 11, 4, and 8 (listed in order by MLS) (P < .01). The most significant findings were an MLS of 2.83 (P = .00029) on chromosome 17q, near the serotonin transporter (5-hydroxytryptamine transporter [5-HTT]), and an MLS of 2.54 (P = .00059) on 5p. The present follow-up genome scan, which used a consistent research design across studies and examined the largest ASD sample collection reported to date, gave either equivalent or marginally increased evidence for linkage at several chromosomal regions implicated in our previous scan but eliminated evidence for linkage at other regions.

Original languageEnglish
Pages (from-to)886-897
Number of pages12
JournalAmerican Journal of Human Genetics
Volume73
Issue number4
DOIs
StatePublished - 1 Oct 2003
Externally publishedYes

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