A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response

Analisa DiFeo, Lauren Feld, Estefania Rodriguez, Christine Wang, David G. Beer, John A. Martignetti, Goutham Narla

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Kruppel-like factor 6 (KLF6) is a tumor suppressor gene that is functionally inactivated in human cancer by loss of heterozygosity, somatic mutation, decreased expression, and increased alternative splicing into an oncogenic splice variant, KLF6-SV1. Here we show that increased expression of KLF6-SV1 is associated with decreased survival in patients with lung adenocarcinoma. In addition, KLF6-SV1 is a novel antiapoptotic protein in lung cancer cell lines, and targeted reduction of KLF6-SV1 using siRNA induces apoptosis both alone and in combination with the chemotherapeutic drug cisplatin. Together, these findings highlight a critical role for KLF6-SV1 in lung cancer, and show a potential novel therapeutic strategy for the treatment of lung cancer.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalCancer Research
Volume68
Issue number4
DOIs
StatePublished - 15 Feb 2008

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