A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

Y. Li; D. A. Lacerda; M. L. Warman; D. R. Beier; H. Yoshioka; Y. Ninomiya; J. T. Oxford; N. P. Morris; K. Andrikopoulos; F. Ramirez; B. B. Wardell; G. D. Lifferth; C. Teuscher; S. R. Woodward; B. A. Taylor; R. E. Seegmiller; B. R. Olsen

doi:10.1016/0092-8674(95)90492-1

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

Y. Li
, D. A. Lacerda
, M. L. Warman
, D. R. Beier
, H. Yoshioka
, Y. Ninomiya
, J. T. Oxford
, N. P. Morris
, K. Andrikopoulos
, F. Ramirez
, B. B. Wardell
, G. D. Lifferth
, C. Teuscher
, S. R. Woodward
, B. A. Taylor
, R. E. Seegmiller
, B. R. Olsen

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

Abstract

Mice that are homozygous for the autosomal recessive chondrodysplasia (cho) mutation die at birth with abnormalities in cartilage of limbs, ribs, mandible, and trachea. Limb bones of newborn cho/cho mice are wider at the metaphyses than normal bones and only about half the normal length. By linkage analysis, the cho gene and the gene encoding the α1 (XI) chain of cartilage collagen XI were mapped to the same region of chromosome 3. Deletion of a cytidine residue about 570 nt downstream of the translation initiation codon in cho α1(XI) mRNA causes a reading frame shift and introduces a premature stop codon. The data demonstrate that collagen XI is essential for normal formation of cartilage collagen fibrils and the cohesive properties of cartilage. The results also suggest that the normal differentiation and spatial organization of growth plate chondrocytes is critially dependent on the presence of type XI collagen in cartilage extracellular matrix.

Original language	English
Pages (from-to)	423-430
Number of pages	8
Journal	Cell
Volume	80
Issue number	3
DOIs	https://doi.org/10.1016/0092-8674(95)90492-1
State	Published - 10 Feb 1995

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Li, Y., Lacerda, D. A., Warman, M. L., Beier, D. R., Yoshioka, H., Ninomiya, Y., Oxford, J. T., Morris, N. P., Andrikopoulos, K., Ramirez, F., Wardell, B. B., Lifferth, G. D., Teuscher, C., Woodward, S. R., Taylor, B. A., Seegmiller, R. E., & Olsen, B. R. (1995). A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell, 80(3), 423-430. https://doi.org/10.1016/0092-8674(95)90492-1

@article{c377740e30254cddbdddbdc4965b5bd2,

title = "A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis",

abstract = "Mice that are homozygous for the autosomal recessive chondrodysplasia (cho) mutation die at birth with abnormalities in cartilage of limbs, ribs, mandible, and trachea. Limb bones of newborn cho/cho mice are wider at the metaphyses than normal bones and only about half the normal length. By linkage analysis, the cho gene and the gene encoding the α1 (XI) chain of cartilage collagen XI were mapped to the same region of chromosome 3. Deletion of a cytidine residue about 570 nt downstream of the translation initiation codon in cho α1(XI) mRNA causes a reading frame shift and introduces a premature stop codon. The data demonstrate that collagen XI is essential for normal formation of cartilage collagen fibrils and the cohesive properties of cartilage. The results also suggest that the normal differentiation and spatial organization of growth plate chondrocytes is critially dependent on the presence of type XI collagen in cartilage extracellular matrix.",

author = "Y. Li and Lacerda, \{D. A.\} and Warman, \{M. L.\} and Beier, \{D. R.\} and H. Yoshioka and Y. Ninomiya and Oxford, \{J. T.\} and Morris, \{N. P.\} and K. Andrikopoulos and F. Ramirez and Wardell, \{B. B.\} and Lifferth, \{G. D.\} and C. Teuscher and Woodward, \{S. R.\} and Taylor, \{B. A.\} and Seegmiller, \{R. E.\} and Olsen, \{B. R.\}",

note = "Funding Information: This study was supported by grants from the National Institutes of Health AR36819 and AR36820 (B. R. O.), GM38862 (N. P. M.), HD21926 and HD27275 (C. T.), CA33093 (B. A. T.), AR38648 (F. R.), a grant from Shriners' Hospital, and funds from the Professional Development Fund of Brigham Young University (R. E. S.). M. Jakoulov provided expert secretarial assistance. The monoclonal antibody against al(ll) collagen (2B1) was generously provided by R. Mayne.",

year = "1995",

month = feb,

day = "10",

doi = "10.1016/0092-8674(95)90492-1",

language = "English",

volume = "80",

pages = "423--430",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "3",

}

Li, Y, Lacerda, DA, Warman, ML, Beier, DR, Yoshioka, H, Ninomiya, Y, Oxford, JT, Morris, NP, Andrikopoulos, K, Ramirez, F, Wardell, BB, Lifferth, GD, Teuscher, C, Woodward, SR, Taylor, BA, Seegmiller, RE & Olsen, BR 1995, 'A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis', Cell, vol. 80, no. 3, pp. 423-430. https://doi.org/10.1016/0092-8674(95)90492-1

TY - JOUR

T1 - A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

AU - Li, Y.

AU - Lacerda, D. A.

AU - Warman, M. L.

AU - Beier, D. R.

AU - Yoshioka, H.

AU - Ninomiya, Y.

AU - Oxford, J. T.

AU - Morris, N. P.

AU - Andrikopoulos, K.

AU - Ramirez, F.

AU - Wardell, B. B.

AU - Lifferth, G. D.

AU - Teuscher, C.

AU - Woodward, S. R.

AU - Taylor, B. A.

AU - Seegmiller, R. E.

AU - Olsen, B. R.

N1 - Funding Information: This study was supported by grants from the National Institutes of Health AR36819 and AR36820 (B. R. O.), GM38862 (N. P. M.), HD21926 and HD27275 (C. T.), CA33093 (B. A. T.), AR38648 (F. R.), a grant from Shriners' Hospital, and funds from the Professional Development Fund of Brigham Young University (R. E. S.). M. Jakoulov provided expert secretarial assistance. The monoclonal antibody against al(ll) collagen (2B1) was generously provided by R. Mayne.

PY - 1995/2/10

Y1 - 1995/2/10

N2 - Mice that are homozygous for the autosomal recessive chondrodysplasia (cho) mutation die at birth with abnormalities in cartilage of limbs, ribs, mandible, and trachea. Limb bones of newborn cho/cho mice are wider at the metaphyses than normal bones and only about half the normal length. By linkage analysis, the cho gene and the gene encoding the α1 (XI) chain of cartilage collagen XI were mapped to the same region of chromosome 3. Deletion of a cytidine residue about 570 nt downstream of the translation initiation codon in cho α1(XI) mRNA causes a reading frame shift and introduces a premature stop codon. The data demonstrate that collagen XI is essential for normal formation of cartilage collagen fibrils and the cohesive properties of cartilage. The results also suggest that the normal differentiation and spatial organization of growth plate chondrocytes is critially dependent on the presence of type XI collagen in cartilage extracellular matrix.

AB - Mice that are homozygous for the autosomal recessive chondrodysplasia (cho) mutation die at birth with abnormalities in cartilage of limbs, ribs, mandible, and trachea. Limb bones of newborn cho/cho mice are wider at the metaphyses than normal bones and only about half the normal length. By linkage analysis, the cho gene and the gene encoding the α1 (XI) chain of cartilage collagen XI were mapped to the same region of chromosome 3. Deletion of a cytidine residue about 570 nt downstream of the translation initiation codon in cho α1(XI) mRNA causes a reading frame shift and introduces a premature stop codon. The data demonstrate that collagen XI is essential for normal formation of cartilage collagen fibrils and the cohesive properties of cartilage. The results also suggest that the normal differentiation and spatial organization of growth plate chondrocytes is critially dependent on the presence of type XI collagen in cartilage extracellular matrix.

UR - https://www.scopus.com/pages/publications/0028815297

U2 - 10.1016/0092-8674(95)90492-1

DO - 10.1016/0092-8674(95)90492-1

M3 - Article

C2 - 7859283

AN - SCOPUS:0028815297

SN - 0092-8674

VL - 80

SP - 423

EP - 430

JO - Cell

JF - Cell

IS - 3

ER -

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

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