A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin

The “Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium

doi:10.1038/s41684-024-01474-4

A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin

The “Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Lab Animal
Volume	53
Issue number	12
DOIs	https://doi.org/10.1038/s41684-024-01474-4
State	Published - Dec 2024
Externally published	Yes

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10.1038/s41684-024-01474-4

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title = "A facility for laboratory mice with a natural microbiome at Charit{\'e} – Universit{\"a}tsmedizin Berlin",

abstract = "Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charit{\'e} – Universit{\"a}tsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.",

author = "\{The “Charit{\'e} 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium\} and Natascha Drude and Stefan Nagel-Riedasch and Rosshart, \{Stephan P.\} and Andreas Diefenbach and Gerald Willimsky and Ulf T{\"o}lch and Gilbert Sch{\"o}nfelder and Rosshart, \{Stephan P.\} and Bastian Opitz and Dominik M{\"u}ller and Mall, \{Marcus A.\} and Lars Lewejohann and Marina Kolesnichenko and Frank Heppner and Christoph Harms and Duerr, \{Claudia U.\} and Kai Diederich and Stefan Jordan",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41684-024-01474-4",

language = "English",

volume = "53",

pages = "351--354",

journal = "Lab Animal",

issn = "0093-7355",

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T1 - A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin

AU - The “Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium

AU - Drude, Natascha

AU - Nagel-Riedasch, Stefan

AU - Rosshart, Stephan P.

AU - Diefenbach, Andreas

AU - Willimsky, Gerald

AU - Tölch, Ulf

AU - Schönfelder, Gilbert

AU - Rosshart, Stephan P.

AU - Opitz, Bastian

AU - Müller, Dominik

AU - Mall, Marcus A.

AU - Lewejohann, Lars

AU - Kolesnichenko, Marina

AU - Heppner, Frank

AU - Harms, Christoph

AU - Duerr, Claudia U.

AU - Diederich, Kai

AU - Jordan, Stefan

PY - 2024/12

Y1 - 2024/12

N2 - Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.

AB - Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.

UR - https://www.scopus.com/pages/publications/85208969391

U2 - 10.1038/s41684-024-01474-4

DO - 10.1038/s41684-024-01474-4

M3 - Comment/debate

C2 - 39533119

AN - SCOPUS:85208969391

SN - 0093-7355

VL - 53

SP - 351

EP - 354

JO - Lab Animal

JF - Lab Animal

IS - 12

ER -

A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin

Abstract

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