Abstract
Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine.These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.
Original language | English |
---|---|
Pages (from-to) | 77-84 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 277 |
Issue number | 1-2 |
DOIs | |
State | Published - 15 Dec 2014 |
Keywords
- Alzheimer's disease
- Dual vaccine
- Immune responses
- Influenza
- Memory T cells