A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

Hayk Davtyan, Anahit Ghochikyan, Armine Hovakimyan, Arpine Davtyan, Richard Cadagan, Annette M. Marleau, Randy A. Albrecht, Adolfo García-Sastre, Michael G. Agadjanyan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine.These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalJournal of Neuroimmunology
Volume277
Issue number1-2
DOIs
StatePublished - 15 Dec 2014

Keywords

  • Alzheimer's disease
  • Dual vaccine
  • Immune responses
  • Influenza
  • Memory T cells

Fingerprint

Dive into the research topics of 'A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory'. Together they form a unique fingerprint.

Cite this