A Drosophila approach to thyroid cancer therapeutics

Tirtha K. Das; Ross L. Cagan

doi:10.1016/j.ddtec.2012.09.004

A Drosophila approach to thyroid cancer therapeutics

Tirtha K. Das, Ross L. Cagan

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.

Original language	English
Pages (from-to)	e65-e71
Journal	Drug Discovery Today: Technologies
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.ddtec.2012.09.004
State	Published - Mar 2013

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10.1016/j.ddtec.2012.09.004

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title = "A Drosophila approach to thyroid cancer therapeutics",

abstract = "Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.",

author = "Das, {Tirtha K.} and Cagan, {Ross L.}",

note = "Funding Information: T.K.D. and R.L.C. were supported by NIH grants R01 CA109730 and R01 CA084309 , and American Cancer Society Grant 120616-RSGM-11-018-01-CDD . T.K.D. was also supported by American Cancer Society Grant 120886-PFM-11-137-01-DDC .",

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AU - Cagan, Ross L.

N1 - Funding Information: T.K.D. and R.L.C. were supported by NIH grants R01 CA109730 and R01 CA084309 , and American Cancer Society Grant 120616-RSGM-11-018-01-CDD . T.K.D. was also supported by American Cancer Society Grant 120886-PFM-11-137-01-DDC .

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N2 - Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.

AB - Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.

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A Drosophila approach to thyroid cancer therapeutics

Abstract

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