A double-blind clinical trial of iopamidol versus metrizamide for lumbosacral myelography

B. P. Drayer, C. Vassallo, A. Sudilovsky, J. S. Luther, R. H. Wilkins, S. Allen, M. Bates

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A double-blind study was performed to compare metrizamide with the new iodinated water-soluble nonionic contrast medium, iopamidol, for conventional and computerized tomography lumbosacral myelography. Both contrast agents were used in 30 patients, and were equivalent in terms of image quality and clinical accuracy. Headaches and nausea were less severe using iopamidol. The most striking difference was found in adverse neurobehavioral reactions and associated electroencephalographic abnormalities, which were noted in 17% of the metrizamide group but were not seen with the use of iopamidol. Iopamidol appears to be superior to metrizamide for intrathecal applications. An explanation of the differential neurotoxicity is provided.

Original languageEnglish
Pages (from-to)531-537
Number of pages7
JournalUnknown Journal
Volume58
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

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