TY - JOUR
T1 - A dimensional approach to the autism spectrum
AU - Hollander, Eric
AU - Cartwright, Charles
AU - Wong, Cheryl M.
AU - Decaria, Concerta M.
AU - Delgiudice-Asch, Gina
AU - Buchsbaum, Monte S.
AU - Aronowitz, Bonnie R.
PY - 1998
Y1 - 1998
N2 - Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.
AB - Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.
UR - http://www.scopus.com/inward/record.url?scp=0032455143&partnerID=8YFLogxK
U2 - 10.1017/S1092852900005678
DO - 10.1017/S1092852900005678
M3 - Review article
AN - SCOPUS:0032455143
SN - 1092-8529
VL - 3
SP - 22
EP - 39
JO - CNS Spectrums
JF - CNS Spectrums
IS - 3
ER -