A diffusion tensor MRI study of basal ganglia from patients with ADEM

Markus Holtmannspötter; Matilde Inglese; Marco Rovaris; Maria Assunta Rocca; Maria Codella; Massimo Filippi

doi:10.1016/S0022-510X(02)00310-6

A diffusion tensor MRI study of basal ganglia from patients with ADEM

Markus Holtmannspötter, Matilde Inglese, Marco Rovaris, Maria Assunta Rocca, Maria Codella, Massimo Filippi

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity (D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ (p=0.02) and lower D̄ histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	206
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(02)00310-6
State	Published - 15 Jan 2003
Externally published	Yes

Keywords

Acute disseminated encephalomyelitis
Basal ganglia
Diffusion tensor MRI
Magnetic resonance imaging
Multiple sclerosis

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10.1016/S0022-510X(02)00310-6

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title = "A diffusion tensor MRI study of basal ganglia from patients with ADEM",

abstract = "Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ({\=D}) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average {\=D} (p=0.02) and lower {\=D} histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.",

keywords = "Acute disseminated encephalomyelitis, Basal ganglia, Diffusion tensor MRI, Magnetic resonance imaging, Multiple sclerosis",

author = "Markus Holtmannsp{\"o}tter and Matilde Inglese and Marco Rovaris and Rocca, {Maria Assunta} and Maria Codella and Massimo Filippi",

note = "Funding Information: This study was partially supported from a grant of the Fondazione Italiana Sclerosi Multipla (contract number: 2000/R/37). We are also grateful to Dr. Fabrizio Salvi and Prof. Gianluigi Mancardi for referring patients with ADEM.",

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doi = "10.1016/S0022-510X(02)00310-6",

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T1 - A diffusion tensor MRI study of basal ganglia from patients with ADEM

AU - Holtmannspötter, Markus

AU - Inglese, Matilde

AU - Rovaris, Marco

AU - Rocca, Maria Assunta

AU - Codella, Maria

AU - Filippi, Massimo

N1 - Funding Information: This study was partially supported from a grant of the Fondazione Italiana Sclerosi Multipla (contract number: 2000/R/37). We are also grateful to Dr. Fabrizio Salvi and Prof. Gianluigi Mancardi for referring patients with ADEM.

PY - 2003/1/15

Y1 - 2003/1/15

N2 - Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity (D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ (p=0.02) and lower D̄ histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

AB - Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity (D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ (p=0.02) and lower D̄ histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

KW - Acute disseminated encephalomyelitis

KW - Basal ganglia

KW - Diffusion tensor MRI

KW - Magnetic resonance imaging

KW - Multiple sclerosis

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

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A diffusion tensor MRI study of basal ganglia from patients with ADEM

Abstract

Keywords

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