TY - JOUR
T1 - A Diffusion Tensor Imaging Study of White Matter in Early-Onset Schizophrenia
AU - Kyriakopoulos, Marinos
AU - Vyas, Nora S.
AU - Barker, Gareth J.
AU - Chitnis, Xavier A.
AU - Frangou, Sophia
N1 - Funding Information:
The study was funded by a grant from the National Alliance of Research on Schizophrenia and Depression to SF.
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Background: Voxel-based analysis of diffusion tensor magnetic resonance imaging (DTI) data was used to examine white matter integrity in adolescents with early-onset schizophrenia (EOS), defined as schizophrenia beginning before the 18th birthday. Methods: Nineteen patients with EOS, aged 13 to 19, were compared with 20 healthy volunteers matched for age, gender, and parental socioeconomic status. Diffusion tensor magnetic resonance imaging data were acquired on a GE Signa NVi 1.5 Tesla system (General Electric, Milwaukee, Wisconsin). Maps of fractional anisotropy (FA) were registered into standard space, and group differences were examined using a nonparametric statistical approach. Results: In comparison with healthy participants, EOS patients had significantly lower FA in the white matter of the parietal association cortex bilaterally and in the left middle cerebellar penduncle. No areas with significantly higher FA in patients were identified. Conclusions: Parietal and cerebellar white matter abnormalities may contribute to the emergence of psychotic symptoms in adolescence.
AB - Background: Voxel-based analysis of diffusion tensor magnetic resonance imaging (DTI) data was used to examine white matter integrity in adolescents with early-onset schizophrenia (EOS), defined as schizophrenia beginning before the 18th birthday. Methods: Nineteen patients with EOS, aged 13 to 19, were compared with 20 healthy volunteers matched for age, gender, and parental socioeconomic status. Diffusion tensor magnetic resonance imaging data were acquired on a GE Signa NVi 1.5 Tesla system (General Electric, Milwaukee, Wisconsin). Maps of fractional anisotropy (FA) were registered into standard space, and group differences were examined using a nonparametric statistical approach. Results: In comparison with healthy participants, EOS patients had significantly lower FA in the white matter of the parietal association cortex bilaterally and in the left middle cerebellar penduncle. No areas with significantly higher FA in patients were identified. Conclusions: Parietal and cerebellar white matter abnormalities may contribute to the emergence of psychotic symptoms in adolescence.
KW - Adolescence
KW - age of onset
KW - parietal
UR - http://www.scopus.com/inward/record.url?scp=38949147856&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2007.05.021
DO - 10.1016/j.biopsych.2007.05.021
M3 - Article
C2 - 17662964
AN - SCOPUS:38949147856
SN - 0006-3223
VL - 63
SP - 519
EP - 523
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5
ER -