A developmental view of microRNA function

Yong Zhao; Deepak Srivastava

doi:10.1016/j.tibs.2007.02.006

A developmental view of microRNA function

Yong Zhao
, Deepak Srivastava

Research output: Contribution to journal › Review article › peer-review

513 Scopus citations

Abstract

MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.

Original language	English
Pages (from-to)	189-197
Number of pages	9
Journal	Trends in Biochemical Sciences
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.tibs.2007.02.006
State	Published - Apr 2007
Externally published	Yes

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10.1016/j.tibs.2007.02.006

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title = "A developmental view of microRNA function",

abstract = "MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.",

author = "Yong Zhao and Deepak Srivastava",

note = "Funding Information: We thank B. Taylor for assistance with manuscript preparation, members of the Srivastava laboratory for discussions, insight and reviewing of the manuscript, and S. Ordway and G. Howard for editorial assistance. Y.Z. is a California Institute of Regenerative Medicine (CIRM) Post-Doctoral Scholar; D.S. is supported by grants from the NHLBI/NIH and the March of Dimes Birth Defects Foundation; D.S. is an Established Investigator of the American Heart Association.",

year = "2007",

month = apr,

doi = "10.1016/j.tibs.2007.02.006",

language = "English",

volume = "32",

pages = "189--197",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier Ltd.",

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T1 - A developmental view of microRNA function

AU - Zhao, Yong

AU - Srivastava, Deepak

N1 - Funding Information: We thank B. Taylor for assistance with manuscript preparation, members of the Srivastava laboratory for discussions, insight and reviewing of the manuscript, and S. Ordway and G. Howard for editorial assistance. Y.Z. is a California Institute of Regenerative Medicine (CIRM) Post-Doctoral Scholar; D.S. is supported by grants from the NHLBI/NIH and the March of Dimes Birth Defects Foundation; D.S. is an Established Investigator of the American Heart Association.

PY - 2007/4

Y1 - 2007/4

N2 - MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.

AB - MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.

UR - https://www.scopus.com/pages/publications/34147149312

U2 - 10.1016/j.tibs.2007.02.006

DO - 10.1016/j.tibs.2007.02.006

M3 - Review article

C2 - 17350266

AN - SCOPUS:34147149312

SN - 0968-0004

VL - 32

SP - 189

EP - 197

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 4

ER -

A developmental view of microRNA function

Abstract

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