TY - JOUR
T1 - A developmental view of microRNA function
AU - Zhao, Yong
AU - Srivastava, Deepak
N1 - Funding Information:
We thank B. Taylor for assistance with manuscript preparation, members of the Srivastava laboratory for discussions, insight and reviewing of the manuscript, and S. Ordway and G. Howard for editorial assistance. Y.Z. is a California Institute of Regenerative Medicine (CIRM) Post-Doctoral Scholar; D.S. is supported by grants from the NHLBI/NIH and the March of Dimes Birth Defects Foundation; D.S. is an Established Investigator of the American Heart Association.
PY - 2007/4
Y1 - 2007/4
N2 - MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.
AB - MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.
UR - http://www.scopus.com/inward/record.url?scp=34147149312&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2007.02.006
DO - 10.1016/j.tibs.2007.02.006
M3 - Review article
C2 - 17350266
AN - SCOPUS:34147149312
SN - 0968-0004
VL - 32
SP - 189
EP - 197
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 4
ER -