A developmental view of microRNA function

Yong Zhao, Deepak Srivastava

Research output: Contribution to journalReview articlepeer-review

496 Scopus citations

Abstract

MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalTrends in Biochemical Sciences
Volume32
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Dive into the research topics of 'A developmental view of microRNA function'. Together they form a unique fingerprint.

Cite this