A Determined “Hesitation” on H3K27me3 Empowers Stem Cells to Differentiate

Xin Huang; Jianlong Wang

doi:10.1016/j.molcel.2017.04.003

A Determined “Hesitation” on H3K27me3 Empowers Stem Cells to Differentiate

Xin Huang
, Jianlong Wang

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

To uncover the precise mechanisms coordinating proliferation and fate choice of stem cells, in this issue of Molecular Cell and in an accompanying paper in Cell Reports, Mazo and colleagues (Petruk et al. 2017a, 2017b) reveal that delayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiation.

Original language	English
Pages (from-to)	165-166
Number of pages	2
Journal	Molecular Cell
Volume	66
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2017.04.003
State	Published - 20 Apr 2017

Keywords

DNA replication
ESC
H3K27me3
HPC
KDM6A
KDM6B
PRC2
UTX
cell cycle
stem cell differentiation

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10.1016/j.molcel.2017.04.003

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@article{980a47e23100446783fa0fa6137d4ce6,

title = "A Determined {\textquotedblleft}Hesitation{\textquotedblright} on H3K27me3 Empowers Stem Cells to Differentiate",

abstract = "To uncover the precise mechanisms coordinating proliferation and fate choice of stem cells, in this issue of Molecular Cell and in an accompanying paper in Cell Reports, Mazo and colleagues (Petruk et al. 2017a, 2017b) reveal that delayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiation.",

keywords = "DNA replication, ESC, H3K27me3, HPC, KDM6A, KDM6B, PRC2, UTX, cell cycle, stem cell differentiation",

author = "Xin Huang and Jianlong Wang",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = apr,

day = "20",

doi = "10.1016/j.molcel.2017.04.003",

language = "English",

volume = "66",

pages = "165--166",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "2",

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TY - JOUR

T1 - A Determined “Hesitation” on H3K27me3 Empowers Stem Cells to Differentiate

AU - Huang, Xin

AU - Wang, Jianlong

PY - 2017/4/20

Y1 - 2017/4/20

N2 - To uncover the precise mechanisms coordinating proliferation and fate choice of stem cells, in this issue of Molecular Cell and in an accompanying paper in Cell Reports, Mazo and colleagues (Petruk et al. 2017a, 2017b) reveal that delayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiation.

AB - To uncover the precise mechanisms coordinating proliferation and fate choice of stem cells, in this issue of Molecular Cell and in an accompanying paper in Cell Reports, Mazo and colleagues (Petruk et al. 2017a, 2017b) reveal that delayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiation.

KW - DNA replication

KW - ESC

KW - H3K27me3

KW - HPC

KW - KDM6A

KW - KDM6B

KW - PRC2

KW - UTX

KW - cell cycle

KW - stem cell differentiation

UR - https://www.scopus.com/pages/publications/85018641812

U2 - 10.1016/j.molcel.2017.04.003

DO - 10.1016/j.molcel.2017.04.003

M3 - Short survey

C2 - 28431228

AN - SCOPUS:85018641812

SN - 1097-2765

VL - 66

SP - 165

EP - 166

JO - Molecular Cell

JF - Molecular Cell

IS - 2

ER -

A Determined “Hesitation” on H3K27me3 Empowers Stem Cells to Differentiate

Abstract

Keywords

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