A Detailed Clinical Case of Localized Prostate Tumors Treated with Nanoparticle-Assisted Sub-Ablative Laser Ablation

Yara Kadria-Vili, Jon A. Schwartz, Thomas J. Polascik, Glenn P. Goodrich, David Jorden, Diane Pinder, Naomi J. Halas, Ardeshir R. Rastinehad

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

AuroLase® Therapy—a nanoparticle-enabled focal therapy—has the potential to safely and effectively treat localized prostate cancer (PCa), preserving baseline functionality. This article presents a detailed case of localized PCa treated with AuroLase, providing insight on expectations from the diagnosis of PCa to one year post-treatment. AuroLase Therapy is a two-day treatment consisting of a systemic infusion of gold nanoshells (~150-nm hydrodynamic diameter) on Day 1, and sub-ablative laser treatment on Day 2. Multiparametric MRI (mpMRI) was used for tumor visualization, treatment planning, and therapy response assessment. The PCa was targeted with a MR/Ultrasound-fusion (MR/US) transperineal approach. Successful treatment was confirmed at 6 and 12 months post-treatment by the absence of disease in MR/US targeted biopsies. On the mpMRI, confined void space was evident, an indication of necrotic tissues encompassing the treated lesion, which was completely resolved at 12 months, forming a band-like scar with no evidence of recurrent tumor. The patient’s urinary and sexual functions were unchanged. During the one-year follow-up, changes on the DCE sequence and in the Ktrans and ADC values assist in qualitatively and quantitatively evaluating tissue changes. The results highlight the potential of gold-nanoparticle-enabled sub-ablative laser treatment to target and control localized PCa, maintain quality of life, and preserve baseline functionality.

Original languageEnglish
Article number1261
JournalNanomaterials
Volume14
Issue number15
DOIs
StatePublished - Aug 2024
Externally publishedYes

Keywords

  • ADC
  • AuroLase Therapy
  • AuroShell Particles
  • Ktrans
  • clinical trial
  • dynamic contrast enhancement
  • focal ablation
  • multiparametric MRI
  • nanoshells
  • prostate cancer

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