A cross-species approach to disorders affecting brain and behaviour

Orrin Devinsky; Jordyn M. Boesch; Sofia Cerda-Gonzalez; Barbara Coffey; Kathryn Davis; Daniel Friedman; Brian Hainline; Katherine Houpt; Daniel Lieberman; Pamela Perry; Harald Prüss; Martin A. Samuels; Gary W. Small; Holger Volk; Artur Summerfield; Charles Vite; Thomas Wisniewski; Barbara Natterson-Horowitz

doi:10.1038/s41582-018-0074-z

A cross-species approach to disorders affecting brain and behaviour

Orrin Devinsky, Jordyn M. Boesch, Sofia Cerda-Gonzalez, Barbara Coffey, Kathryn Davis, Daniel Friedman, Brian Hainline, Katherine Houpt, Daniel Lieberman, Pamela Perry, Harald Prüss, Martin A. Samuels, Gary W. Small, Holger Volk, Artur Summerfield, Charles Vite, Thomas Wisniewski, Barbara Natterson-Horowitz

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.

Original language	English
Pages (from-to)	677-686
Number of pages	10
Journal	Nature Reviews Neurology
Volume	14
Issue number	11
DOIs	https://doi.org/10.1038/s41582-018-0074-z
State	Published - 1 Nov 2018
Externally published	Yes

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Devinsky, O., Boesch, J. M., Cerda-Gonzalez, S., Coffey, B., Davis, K., Friedman, D., Hainline, B., Houpt, K., Lieberman, D., Perry, P., Prüss, H., Samuels, M. A., Small, G. W., Volk, H., Summerfield, A., Vite, C., Wisniewski, T., & Natterson-Horowitz, B. (2018). A cross-species approach to disorders affecting brain and behaviour. Nature Reviews Neurology, 14(11), 677-686. https://doi.org/10.1038/s41582-018-0074-z

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title = "A cross-species approach to disorders affecting brain and behaviour",

abstract = "Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.",

author = "Orrin Devinsky and Boesch, \{Jordyn M.\} and Sofia Cerda-Gonzalez and Barbara Coffey and Kathryn Davis and Daniel Friedman and Brian Hainline and Katherine Houpt and Daniel Lieberman and Pamela Perry and Harald Pr{\"u}ss and Samuels, \{Martin A.\} and Small, \{Gary W.\} and Holger Volk and Artur Summerfield and Charles Vite and Thomas Wisniewski and Barbara Natterson-Horowitz",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Nature Limited.",

year = "2018",

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doi = "10.1038/s41582-018-0074-z",

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Devinsky, O, Boesch, JM, Cerda-Gonzalez, S, Coffey, B, Davis, K, Friedman, D, Hainline, B, Houpt, K, Lieberman, D, Perry, P, Prüss, H, Samuels, MA, Small, GW, Volk, H, Summerfield, A, Vite, C, Wisniewski, T & Natterson-Horowitz, B 2018, 'A cross-species approach to disorders affecting brain and behaviour', Nature Reviews Neurology, vol. 14, no. 11, pp. 677-686. https://doi.org/10.1038/s41582-018-0074-z

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T1 - A cross-species approach to disorders affecting brain and behaviour

AU - Devinsky, Orrin

AU - Boesch, Jordyn M.

AU - Cerda-Gonzalez, Sofia

AU - Coffey, Barbara

AU - Davis, Kathryn

AU - Friedman, Daniel

AU - Hainline, Brian

AU - Houpt, Katherine

AU - Lieberman, Daniel

AU - Perry, Pamela

AU - Prüss, Harald

AU - Samuels, Martin A.

AU - Small, Gary W.

AU - Volk, Holger

AU - Summerfield, Artur

AU - Vite, Charles

AU - Wisniewski, Thomas

AU - Natterson-Horowitz, Barbara

PY - 2018/11/1

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AB - Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.

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VL - 14

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JO - Nature Reviews Neurology

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A cross-species approach to disorders affecting brain and behaviour

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