A convenient synthesis of the core trisaccharide of the N-glycans

Zhichao Lu, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A convenient synthesis of the core trisaccharide of the N-glycans was described. Orthogonal one-pot glycosylation of three monosaccharide building blocks was performed to furnish β-glucosyl chitobiose, which was then transformed to β-mannosyl chitobiose by intramolecular epimerization of the C-2 position of the β-glucoside. The key glucosyl donor 7c with differentiated 2,3-OH was prepared following the 4,6-O-benzylidene-protected 1,2-orthoester strategy.

Original languageEnglish
Pages (from-to)3320-3323
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number26
DOIs
StatePublished - 29 Jun 2011
Externally publishedYes

Keywords

  • 1,2-Orthoester
  • Core trisaccharide
  • N-Glycan
  • One-pot glycosylation

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