A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression

Joseph Biederman, Carter Petty, Dina R. Hirshfeld-Becker, Aude Henin, Stephen V. Faraone, Danielle Dang, Aleksandra Jakubowski, Jerrold F. Rosenbaum

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background. To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence. Method. Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103). Results. Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD. Conclusions. These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.

Original languageEnglish
Pages (from-to)1141-1152
Number of pages12
JournalPsychological Medicine
Volume36
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Dive into the research topics of 'A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression'. Together they form a unique fingerprint.

Cite this