TY - JOUR
T1 - A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
AU - Biederman, Joseph
AU - Petty, Carter
AU - Hirshfeld-Becker, Dina R.
AU - Henin, Aude
AU - Faraone, Stephen V.
AU - Dang, Danielle
AU - Jakubowski, Aleksandra
AU - Rosenbaum, Jerrold F.
PY - 2006/8
Y1 - 2006/8
N2 - Background. To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence. Method. Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103). Results. Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD. Conclusions. These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.
AB - Background. To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence. Method. Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103). Results. Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD. Conclusions. These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.
UR - http://www.scopus.com/inward/record.url?scp=33746155696&partnerID=8YFLogxK
U2 - 10.1017/S0033291706007781
DO - 10.1017/S0033291706007781
M3 - Article
C2 - 16700966
AN - SCOPUS:33746155696
SN - 0033-2917
VL - 36
SP - 1141
EP - 1152
JO - Psychological Medicine
JF - Psychological Medicine
IS - 8
ER -