A controlled clinical trial of alprazolam for the treatment of anxiety

K. Rickels; I. Csanalosi; P. Greisman; D. Cohen; J. Werblowsky; H. A. Ross; H. Harris

doi:10.1176/ajp.140.1.82

A controlled clinical trial of alprazolam for the treatment of anxiety

K. Rickels
, I. Csanalosi
, P. Greisman
, D. Cohen
, J. Werblowsky
, H. A. Ross
, H. Harris

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.

Original language	English
Pages (from-to)	82-85
Number of pages	4
Journal	Unknown Journal
Volume	140
Issue number	1
DOIs	https://doi.org/10.1176/ajp.140.1.82
State	Published - 1983

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10.1176/ajp.140.1.82

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abstract = "The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.",

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AU - Csanalosi, I.

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AU - Werblowsky, J.

AU - Ross, H. A.

AU - Harris, H.

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AB - The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.

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A controlled clinical trial of alprazolam for the treatment of anxiety

Abstract

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