A controlled clinical trial of alprazolam for the treatment of anxiety

K. Rickels, I. Csanalosi, P. Greisman, D. Cohen, J. Werblowsky, H. A. Ross, H. Harris

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalUnknown Journal
Volume140
Issue number1
DOIs
StatePublished - 1983

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