A continuous model of cortical connectivity

Daniel Moyer, Boris A. Gutman, Joshua Faskowitz, Neda Jahanshad, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

We present a continuous model for structural brain connectivity based on the Poisson point process. The model treats each streamline curve in a tractography as an observed event in connectome space,here a product space of cortical white matter boundaries. We approximate the model parameter via kernel density estimation. To deal with the heavy computational burden,we develop a fast parameter estimation method by pre-computing associated Legendre products of the data,leveraging properties of the spherical heat kernel. We show how our approach can be used to assess the quality of cortical parcellations with respect to connectivty. We further present empirical results that suggest the “discrete” connectomes derived from our model have substantially higher test-retest reliability compared to standard methods.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
EditorsSebastian Ourselin, Leo Joskowicz, Mert R. Sabuncu, William Wells, Gozde Unal
PublisherSpringer Verlag
Pages157-165
Number of pages9
ISBN (Print)9783319467191
DOIs
StatePublished - 2016
Externally publishedYes
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: 21 Oct 201621 Oct 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
Country/TerritoryGreece
CityAthens
Period21/10/1621/10/16

Keywords

  • Diffusion MRI
  • Human connectome
  • Non-parametric estimation

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