A Consensus on Staphylococcus Aureus Exacerbated Atopic Dermatitis and the Need for a Novel Treatment

The skin microbiome is essential for skin barrier function because it inhibits pathogen colonization, and decreased microbiome diversity correlates with increased Staphylococcus aureus (S. aureus) burden and atopic dermatitis (AD) severity. Managing S. aureus-driven AD in clinical practice remains problematic due to complications such as AD exacerbation, impetigo, abscesses, and invasive infections. This project used a modified Delphi process comprising face-to-face discussions followed by a blinded vote to define 5 final consensus statements. A panel of 6 pediatric dermatologists developed a consensus on S. aureus-driven AD exacerbation, challenges in current treatments for AD with secondary bacterial infections, and new developments to improve patient care and outcomes. The panel's 5 consensus statements provide recommendations for dermatologists, Do Not Copy pediatricians, and healthcare providers treating patients with secondary AD clinical practice infected and AD. promoting These recommendations antibiotic stewardship underscore Penalties to mitigate the importance resistance. Apply of The recognizing panel defined and managing a significant S. unmet aureus need skin infection for a single in topical AD therapy effective against all symptoms, including pruritus, S. aureus-driven AD exacerbation, infection, and inflammation, across AD severity levels.