Abstract
The capacity of ouabain to induce cardiac rhythm disorders was compared in both the intact and isolated guinea pig heart. The electrocardiographic changes induced were correlated with ouabain concentration in the perfusing solution, in blood and in the myocardium. In the intact guinea pig the time required for development of ventricular rhythm disorders was inversely proportional to the rate of ouabain infusion. In isolated guinea pig heart preparations the time required for development of ventricular rhythm disorders was inversely proportional to the concentration of ouabain in the perfusate. On the other hand, the myocardial content of ouabain at the time of ventricular rhythm disorders, either in the intact or isolated heart, was independent of the perfusate concentration, rate of infusion, and time required to develop toxicity. The ventricular content of ouabain associated with death in the isolated heart was significantly higher than the ventricular content associated with death in the intact heart. The lethal event in the isolated heart was asystole while in the intact animal, it was ventricular fibrillation.
| Original language | English |
|---|---|
| Pages (from-to) | 162-169 |
| Number of pages | 8 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 207 |
| Issue number | 1 |
| State | Published - 1974 |