TY - JOUR
T1 - A comparison of the effects of timolol and epinephrine on intraocular pressure
AU - Moss, Alan P.
AU - Ritch, Robert
AU - Hargett, Newell A.
AU - Kohn, Alan N.
AU - Smith, Harry
AU - Podos, Steven M.
N1 - Funding Information:
From the Department of Ophthalmology, Mount Sinai School of Medicine of the City University of New York, New York. This study was supported in part by grant EY-02514 and by fellowship grant EY-05128 from the National Eye Institute, National Institutes of Health, Bethesda, Maryland (Dr. Ritch); Fight for Sight fellowship grants F-304 (Dr. Moss) and F-302 (Dr. Hargett); an Earl Wilson Award (Dr. Moss) and Elsie K. Sloate Award (Dr. Hargett) from Fight for Sight, Inc.; and by Merck Sharpe and Dohme Research Laboratories. Dr. Ritch was a Heed Foundation Fellow (1976-1977); Dr. Cohen was a Heed Foundation Fellow (1977-1978).
PY - 1978/10
Y1 - 1978/10
N2 - We conducted a double-masked, six-week crossover study comparing bilateral twice-a-day therapy with timolol maleate (0.1%, 0.25%, and 0.5%) and epinephrine hydrochloride (0.5%, 1.0%, 2.0%) in 36 otherwise untreated patients. Increasing concentrations of each drug were administered until an arbitrary level of control was achieved before each of the six-week follow-up periods. Seventeen patients were controlled by both drugs and four patients were controlled by neither drug. Timolol, but not epinephrine, was effective in ten patients, whereas epinephrine, but not timolol, was effective in two patients. Three patients did not complete the study. The mean decrease in intraocular pressure from baseline was significantly greater with timolol than with epinephrine both before crossover and overall at both the lowest and highest concentrations of drug used. Significant toxicity was produced in four patients during treatment with epinephrine, but in no patients during treatment with timolol.
AB - We conducted a double-masked, six-week crossover study comparing bilateral twice-a-day therapy with timolol maleate (0.1%, 0.25%, and 0.5%) and epinephrine hydrochloride (0.5%, 1.0%, 2.0%) in 36 otherwise untreated patients. Increasing concentrations of each drug were administered until an arbitrary level of control was achieved before each of the six-week follow-up periods. Seventeen patients were controlled by both drugs and four patients were controlled by neither drug. Timolol, but not epinephrine, was effective in ten patients, whereas epinephrine, but not timolol, was effective in two patients. Three patients did not complete the study. The mean decrease in intraocular pressure from baseline was significantly greater with timolol than with epinephrine both before crossover and overall at both the lowest and highest concentrations of drug used. Significant toxicity was produced in four patients during treatment with epinephrine, but in no patients during treatment with timolol.
UR - https://www.scopus.com/pages/publications/0018114190
U2 - 10.1016/0002-9394(78)90294-5
DO - 10.1016/0002-9394(78)90294-5
M3 - Article
C2 - 360846
AN - SCOPUS:0018114190
SN - 0002-9394
VL - 86
SP - 489
EP - 495
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -