A comparison of the effects of timolol and epinephrine on intraocular pressure

Alan P. Moss, Robert Ritch, Newell A. Hargett, Alan N. Kohn, Harry Smith, Steven M. Podos

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


We conducted a double-masked, six-week crossover study comparing bilateral twice-a-day therapy with timolol maleate (0.1%, 0.25%, and 0.5%) and epinephrine hydrochloride (0.5%, 1.0%, 2.0%) in 36 otherwise untreated patients. Increasing concentrations of each drug were administered until an arbitrary level of control was achieved before each of the six-week follow-up periods. Seventeen patients were controlled by both drugs and four patients were controlled by neither drug. Timolol, but not epinephrine, was effective in ten patients, whereas epinephrine, but not timolol, was effective in two patients. Three patients did not complete the study. The mean decrease in intraocular pressure from baseline was significantly greater with timolol than with epinephrine both before crossover and overall at both the lowest and highest concentrations of drug used. Significant toxicity was produced in four patients during treatment with epinephrine, but in no patients during treatment with timolol.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalAmerican Journal of Ophthalmology
Issue number4
StatePublished - Oct 1978
Externally publishedYes


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