A comparison of live and videotape ratings: Clomipramine and haloperidol in autism

L. E. Sanchez, P. B. Adams, S. Uysal, A. Hallin, M. Campbell, A. M. Small

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


This study compared live ratings with ratings of videotapes and compared response to clomipramine with response to haloperidol in 8 subjects, mean age 5.62 years, who met criteria for autism. They were consecutive admissions to a pilot study of clomipramine (n=4) or a double-blind, placebo controlled study of haloperidol (n=4). Live ratings were performed by two raters at the end of the pre-treatment placebo baseline period and at the end of the drug treatment period on the CPRS and the CGI and were videotaped. Employing the same instruments, these videotapes were rated by two raters who did not know the subjects end were blind to study design, treatment, and study phase. Ratings of videotapes significantly differed from live ratings. A treatment effect for haloperidol was detected only on live ratings and not on ratings of videotapes. No treatment effect was detected for clomipramine in either live or videotape ratings.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalPsychopharmacology Bulletin
Issue number2
StatePublished - 1995
Externally publishedYes


  • autism
  • clomipramine
  • haloperidol
  • live vs. videotape ratings


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