A comparative study of a preservative-free latanoprost cationic emulsion (catioprost) and a BAK-preserved latanoprost solution in animal models

Philippe Daull, Ronald Buggage, Grégory Lambert, Marie Odile Faure, Janet Serle, Rong Fang Wang, Jean Sébastien Garrigue

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Purpose: Benzalkonium chloride (BAK), a common preservative in eye drops, can induce ocular surface toxicity that may decrease glaucoma therapy compliance. The ocular hypotensive effect, pharmacokinetic (PK) profiles, and local tolerance of a preservative-free latanoprost 0.005% cationic emulsion (Catioprost®), and a BAK-preserved latanoprost 0.005% solution (Xalatan®), were compared. Methods: The ocular hypotensive effect was evaluated in monkeys with elevated intraocular pressure (IOP) induced by laser photocoagulation of the trabecular meshwork. Each monkey (n=8) received both latanoprost formulations once daily for 5 consecutive treatment days in a crossover design with at least a 2-week washout period between treatments. IOP was measured at baseline (on day 1, no instillation), on vehicle treatment day (day 0), and on treatment days 1, 3, and 5 before drug instillation and then hourly for 6h. In rabbits, the ocular and systemic concentrations of latanoprost free acid were determined following a single instillation and the local tolerance of twice daily instillations over 28 days was assessed. Results: Both the preservative-free and BAK-preserved latanoprost formulations shared the same efficacy profile with the maximum IOP reduction occurring 2h after each morning dose (-15%,-20%, and-26%;-15%,-23%, and-23% on days 1, 3, and 5, respectively) and lasting through 24h. The equivalence in efficacy was confirmed by the PK data demonstrating similar area under the curves (AUCs). While both formulations were well tolerated, the incidence of conjunctival hyperemia was reduced by 42% with the BAK-free latanoprost cationic emulsion. Conclusions: In animal models, a preservative-free latanoprost cationic emulsion was as effective as Xalatan® for lowering IOP with an improved ocular tolerance profile.

Original languageEnglish
Pages (from-to)515-523
Number of pages9
JournalJournal of Ocular Pharmacology and Therapeutics
Volume28
Issue number5
DOIs
StatePublished - 1 Oct 2012

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