A color Doppler analysis of nifedipine-induced posterior ocular blood flow changes in open-angle glaucoma

Richard P. Wilson; Warren J. Chang; Robert C. Sergott; Marlene R. Moster; Courtland M. Schmidt; J. Brent Bond; Alon Harris

doi:10.1097/00061198-199708000-00007

A color Doppler analysis of nifedipine-induced posterior ocular blood flow changes in open-angle glaucoma

Richard P. Wilson, Warren J. Chang, Robert C. Sergott, Marlene R. Moster, Courtland M. Schmidt, J. Brent Bond, Alon Harris

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Purpose: This pilot study used color Doppler imaging to investigate the effects of nifedipine on the posterior ocular blood flow of patients with glaucoma progression at normal intraocular pressures. Patients and Methods: Eighteen patients, 11 men and seven women with a median age of 61.7 years, were imaged before and 6 weeks after the initiation of 30 mg of sustained-release nifedipine (Procardia XL; produced by either Pfizer or Pratt) daily. Results: There was no statistically significant change in the blood velocity of the ophthalmic artery, central retinal artery, and main nasal and temporal short posterior ciliary arteries after treatment with nifedipine. Conclusion: The routine use of nifedipine in patients with normal tension glaucoma progression is not supported by this study.

Original language	English
Pages (from-to)	231-236
Number of pages	6
Journal	Journal of Glaucoma
Volume	6
Issue number	4
DOIs	https://doi.org/10.1097/00061198-199708000-00007
State	Published - Aug 1997
Externally published	Yes

Keywords

Color Doppler
Nifedipine
Normal tension glaucoma
Optic nerve blood

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10.1097/00061198-199708000-00007

Cite this

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title = "A color Doppler analysis of nifedipine-induced posterior ocular blood flow changes in open-angle glaucoma",

abstract = "Purpose: This pilot study used color Doppler imaging to investigate the effects of nifedipine on the posterior ocular blood flow of patients with glaucoma progression at normal intraocular pressures. Patients and Methods: Eighteen patients, 11 men and seven women with a median age of 61.7 years, were imaged before and 6 weeks after the initiation of 30 mg of sustained-release nifedipine (Procardia XL; produced by either Pfizer or Pratt) daily. Results: There was no statistically significant change in the blood velocity of the ophthalmic artery, central retinal artery, and main nasal and temporal short posterior ciliary arteries after treatment with nifedipine. Conclusion: The routine use of nifedipine in patients with normal tension glaucoma progression is not supported by this study.",

keywords = "Color Doppler, Nifedipine, Normal tension glaucoma, Optic nerve blood",

author = "Wilson, {Richard P.} and Chang, {Warren J.} and Sergott, {Robert C.} and Moster, {Marlene R.} and Schmidt, {Courtland M.} and Bond, {J. Brent} and Alon Harris",

year = "1997",

month = aug,

doi = "10.1097/00061198-199708000-00007",

language = "English",

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pages = "231--236",

journal = "Journal of Glaucoma",

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TY - JOUR

T1 - A color Doppler analysis of nifedipine-induced posterior ocular blood flow changes in open-angle glaucoma

AU - Wilson, Richard P.

AU - Chang, Warren J.

AU - Sergott, Robert C.

AU - Moster, Marlene R.

AU - Schmidt, Courtland M.

AU - Bond, J. Brent

AU - Harris, Alon

PY - 1997/8

Y1 - 1997/8

N2 - Purpose: This pilot study used color Doppler imaging to investigate the effects of nifedipine on the posterior ocular blood flow of patients with glaucoma progression at normal intraocular pressures. Patients and Methods: Eighteen patients, 11 men and seven women with a median age of 61.7 years, were imaged before and 6 weeks after the initiation of 30 mg of sustained-release nifedipine (Procardia XL; produced by either Pfizer or Pratt) daily. Results: There was no statistically significant change in the blood velocity of the ophthalmic artery, central retinal artery, and main nasal and temporal short posterior ciliary arteries after treatment with nifedipine. Conclusion: The routine use of nifedipine in patients with normal tension glaucoma progression is not supported by this study.

AB - Purpose: This pilot study used color Doppler imaging to investigate the effects of nifedipine on the posterior ocular blood flow of patients with glaucoma progression at normal intraocular pressures. Patients and Methods: Eighteen patients, 11 men and seven women with a median age of 61.7 years, were imaged before and 6 weeks after the initiation of 30 mg of sustained-release nifedipine (Procardia XL; produced by either Pfizer or Pratt) daily. Results: There was no statistically significant change in the blood velocity of the ophthalmic artery, central retinal artery, and main nasal and temporal short posterior ciliary arteries after treatment with nifedipine. Conclusion: The routine use of nifedipine in patients with normal tension glaucoma progression is not supported by this study.

KW - Color Doppler

KW - Nifedipine

KW - Normal tension glaucoma

KW - Optic nerve blood

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A color Doppler analysis of nifedipine-induced posterior ocular blood flow changes in open-angle glaucoma

Abstract

Keywords

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