A cluster randomised trial of cookstove interventions to improve infant health in Ghana

Darby W. Jack, Kenneth Ayuurebobi Ae-Ngibise, Carlos F. Gould, Ellen Boamah-Kaali, Alison G. Lee, Mohammed Nuhu Mujtaba, Steven Chillrud, Seyram Kaali, Ashlinn K. Quinn, Stephaney Gyaase, Felix Boakye Oppong, Daniel Carrión, Oscar Agyei, Katrin Burkhart, Joseph A. Ana-Aro, Xinhua Liu, Yvonne Afrah Berko, Blair J. Wylie, Seeba Amenga Etego, Robin WhyattSeth Owusu-Agyei, Patrick Kinney, Kwaku Poku Asante

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23 Scopus citations


Introduction Household air pollution from solid fuel combustion for cooking and heating is a leading cause of childhood morbidity and mortality worldwide. We hypothesised that clean cooking interventions delivered during pregnancy would improve child health. Methods We conducted a cluster randomised trial in rural Ghana to test whether providing pregnant women liquefied petroleum gas (LPG) cookstoves or improved biomass cookstoves would reduce personal carbon monoxide and fine particulate pollution exposure, increase birth weight and reduce physician-assessed severe pneumonia in the first 12 months of life, compared with control participants who continued to cook with traditional stoves. Primary analyses were intention-to-treat. The trial was registered with ClinicalTrials.gov and follow-up is complete. Results Enrolment began on 14 April 2014, and ended on 20 August 2015. We enrolled 1414 pregnant women; 361 in the LPG arm, 527 in the improved biomass cookstove arm and 526 controls. We saw no improvement in birth weight (the difference in mean birth weight for LPG arm births was 29 g lighter (95% CI-113 to 56, p=0.51) and for improved biomass arm births was 9 g heavier (95% CI-64 to 82, p=0.81), compared with control newborns) nor severe child pneumonia (the rate ratio for pneumonia in the LPG arm was 0.98 (95% CI 0.58 to 1.70; p=0.95) and for the improved biomass arm was 1.21 (95% CI 0.78 to 1.90; p=0.52), compared with the control arm). Air pollution exposures in the LPG arm remained above WHO health-based targets (LPG median particulate matter less than 2.5 microns in diameter (PM 2.5) 45 μg/m3; IQR 32-65 vs control median PM 2.5 67 μg/m 3;, IQR 46-97). Conclusions Neither prenatally-introduced LPG nor improved biomass cookstoves improved birth weight or reduced severe pneumonia risk in the first 12 months of life. We hypothesise that this is due to lower-than-expected exposure reductions in the intervention arms.

Original languageEnglish
Article numbere005599
JournalBMJ Global Health
Issue number8
StatePublished - 27 Aug 2021


  • child health
  • environmental health
  • epidemiology
  • randomised control trial


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