@article{aede2c8e055245d383f0cb82b8dd190c,
title = "A clinical pharmacologic study of chemotherapy and x-ray therapy in lung cancer",
abstract = "Actinomycin D and 5-fluorouracil, given with x-ray in a dosage regimen sufficient to produce definite but tolerable gastrointestinal and marrow toxicity, did not increase the percentage of patients with carcinoma of the lung showing shrinkage of lesions in the irradiated field. There was no evidence of a more rapid onset of shrinkage of the tumor or of an additive effect at subtotal doses of x-ray. Patient survival was not affected beneficially by the addition of the chemotherapeutic agents. Toxicity was not correlated with responses induced. Patients classified as responders to therapy lived longer than those classified as nonresponders.",
author = "Hall, {Thomas C.} and Dederick, {Margarida M.} and Chalmers, {Thomas C.} and Krant, {Melvin J.} and Shnider, {Bruce I.} and Lynch, {John J.} and Holland, {James F.} and Charles Ross and Koons, {C. Ronald} and Owens, {Albert H.} and Emil Frei and Clyde Brindley and Miller, {Sherwood P.} and Seymour Brenner and Hosley, {Henry F.} and Olson, {Kenneth B.}",
note = "Funding Information: * This study was undertaken by the Eastern Cooperative Group in Solid Tumor Chemotherapy (Chairman, Bruce I. Shnider, M.D.) under the auspices of the Collaborative Clinical Trials Program of the National Cancer Institute. Investigations were supported by Public Health Service Research Grants from the National Cancer Institute. t Departments of Medicine, Harvard Medical School, Boston, Massachusetts and Pondville Hospital, Department of Public Health, Commonwealth of Massachusetts, Walpole, Massachusetts (CA 04739). Publication No. 1297 of Harvard Cancer Commission and No. 275 of Pondville Hospital. Present address: Children{\textquoteright}s Cancer Research Foundation, Boston, Massachusetts. $ Departments of Medicine, Tufts Medical School, and Lemuel Shattuck Hospital, Department of Public Health, Commonwealth of Massachusetts, Boston, Massachusetts (CA 07190). 5 Georgetown University Medical Division, D. C. General Hospital; Department of Medicine Georgetown University School of Medicine and the V. A. Hospital, Washington, D. C. (C.4 02824). ll Department of Medicine A, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York (CA 028210). # Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland (CA 02823). ** Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. tt Department of Medicine, Maimonides Hospital of Brooklyn and Department of Radiology, Downstate Medical Center, New York (CA 05588). $1 Department of Medicine, Subdepartment of Oncology, Albany Medical College of Union University, Albany, New York (CA 06594).",
year = "1967",
month = aug,
doi = "10.1016/0002-9343(67)90163-5",
language = "English",
volume = "43",
pages = "186--193",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",
}