A clinical evaluation of rats dying in the activity-stress ulcer paradigm

William P. Paré; Benjamin H. Natelson; G. P. Vincent; Kile E. Isom

doi:10.1016/0031-9384(80)90282-6

A clinical evaluation of rats dying in the activity-stress ulcer paradigm

William P. Paré, Benjamin H. Natelson, G. P. Vincent, Kile E. Isom

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Rats fed 1 hr daily and housed in running-wheel activity cages exhibited excessive running and developed stomach ulcers as compared to food control, body weight control and home cage control rats. In addition to the observed gastric disease, experimental animals had increased bilirubins, decreased glycogen and decreased serum proteins suggesting that hepatic disease played a role in the lethal consequence of exposing rats to the activity-stress procedure. The decreases in liver glycogen and serum glucose suggested that the terminal problem was related to incipient exhaustion of metabolic substrates.

Original language	English
Pages (from-to)	417-420
Number of pages	4
Journal	Physiology and Behavior
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0031-9384(80)90282-6
State	Published - 1980
Externally published	Yes

Keywords

Activity-stress ulcer
Hepatic disease
Rat
Running activity
Stress ulcer

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10.1016/0031-9384(80)90282-6

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title = "A clinical evaluation of rats dying in the activity-stress ulcer paradigm",

abstract = "Rats fed 1 hr daily and housed in running-wheel activity cages exhibited excessive running and developed stomach ulcers as compared to food control, body weight control and home cage control rats. In addition to the observed gastric disease, experimental animals had increased bilirubins, decreased glycogen and decreased serum proteins suggesting that hepatic disease played a role in the lethal consequence of exposing rats to the activity-stress procedure. The decreases in liver glycogen and serum glucose suggested that the terminal problem was related to incipient exhaustion of metabolic substrates.",

keywords = "Activity-stress ulcer, Hepatic disease, Rat, Running activity, Stress ulcer",

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AU - Paré, William P.

AU - Natelson, Benjamin H.

AU - Vincent, G. P.

AU - Isom, Kile E.

PY - 1980

Y1 - 1980

N2 - Rats fed 1 hr daily and housed in running-wheel activity cages exhibited excessive running and developed stomach ulcers as compared to food control, body weight control and home cage control rats. In addition to the observed gastric disease, experimental animals had increased bilirubins, decreased glycogen and decreased serum proteins suggesting that hepatic disease played a role in the lethal consequence of exposing rats to the activity-stress procedure. The decreases in liver glycogen and serum glucose suggested that the terminal problem was related to incipient exhaustion of metabolic substrates.

AB - Rats fed 1 hr daily and housed in running-wheel activity cages exhibited excessive running and developed stomach ulcers as compared to food control, body weight control and home cage control rats. In addition to the observed gastric disease, experimental animals had increased bilirubins, decreased glycogen and decreased serum proteins suggesting that hepatic disease played a role in the lethal consequence of exposing rats to the activity-stress procedure. The decreases in liver glycogen and serum glucose suggested that the terminal problem was related to incipient exhaustion of metabolic substrates.

KW - Activity-stress ulcer

KW - Hepatic disease

KW - Rat

KW - Running activity

KW - Stress ulcer

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JO - Physiology and Behavior

JF - Physiology and Behavior

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ER -

A clinical evaluation of rats dying in the activity-stress ulcer paradigm

Abstract

Keywords

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