A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma

Julie Chepovetsky; Ajai Chari; Sundar Jagannath; Lakshmi Ramanthan

doi:10.1016/j.cca.2013.08.004

A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma

Julie Chepovetsky, Ajai Chari, Sundar Jagannath, Lakshmi Ramanthan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. Methods: The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. Results: Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. Conclusion: We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.

Original language	English
Pages (from-to)	233-235
Number of pages	3
Journal	Clinica Chimica Acta
Volume	425
DOIs	https://doi.org/10.1016/j.cca.2013.08.004
State	Published - 21 Oct 2013

Keywords

Biclonal myeloma
IgD
Immunofixation
Isotype switch
Multiple myeloma

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title = "A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma",

abstract = "Background: Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. Methods: The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. Results: Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. Conclusion: We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.",

keywords = "Biclonal myeloma, IgD, Immunofixation, Isotype switch, Multiple myeloma",

author = "Julie Chepovetsky and Ajai Chari and Sundar Jagannath and Lakshmi Ramanthan",

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T1 - A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma

AU - Chepovetsky, Julie

AU - Chari, Ajai

AU - Jagannath, Sundar

AU - Ramanthan, Lakshmi

PY - 2013/10/21

Y1 - 2013/10/21

N2 - Background: Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. Methods: The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. Results: Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. Conclusion: We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.

AB - Background: Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. Methods: The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. Results: Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. Conclusion: We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.

KW - Biclonal myeloma

KW - IgD

KW - Immunofixation

KW - Isotype switch

KW - Multiple myeloma

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DO - 10.1016/j.cca.2013.08.004

M3 - Article

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AN - SCOPUS:84883545259

SN - 0009-8981

VL - 425

SP - 233

EP - 235

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma

Abstract

Keywords

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