A case of chronic liver disease due to tolazamide

Naomi L. Nakao, Alvin M. Gelb, Richard J. Stenger, Jerome H. Siegel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Although chlorpropamide and tolbutamide are well recognized as causes of hepatotoxicity, there are only 3 reported cases of hepatic injury caused by a third oral hypoglycemic agent, tolazamide. In 2 of these cases, the liver-function tests returned to normal when the drug was discontinued. In the third case, the patient had cholestasis from chJorpropamide before administration of tolazamide and developed chronic liver disease. We are reporting the second instance of chronic liver disease induced by tolazamide. Our patient had been taking chlorpropamide, but she had no evidence of liver disease before administration of tolazamide. Tolazamide should be considered as a drug capable of producing hepatotoxicity that on occasion may be chronic.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
Issue number1
StatePublished - Jul 1985
Externally publishedYes


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