@article{4a49a3cba0fe40d994f2cc006bac1570,
title = "A case of an Epstein-Barr virus (EBV) genome-carrying lymphoma in an Israeli Arab child",
abstract = "Epstein-Barr virus (EBV) DNA (82 genome equivalents/cell) and EBNA (EBV determined nuclear antigen) were found in tumor tissue from an Israeli Arab child with Burkitt's lymphoma. A lymphoma cell line (LB-132) carrying the EBV genome was established from tumor tissue from this patient. This line resembled other previously established and characterised Burkitt's lymphoma lines. Our results suggest that EBV-carrying lymphoma which occurs endemically in Africa occurs sporadically throughout the world.",
author = "Natan Goldblum and Hannah Ben-Bassat and Stella Mitrani and Maria Andersson-Anvret and Tamar Goldblum and Esther Aghai and Bracha Ramot and George Klein",
note = "Funding Information: THE EPSTEIN--BARR virus (EBV) has been found to be associated with two human malignant diseases: African Burldtt's lymphoma (BL) and nasopharyngeal carcinoma \[1-3\]. About 97% of the African Burkitt's lymphoma biopsies tested contained the EBV genome, with 38 genome equivalents per cell, on the average \[1-3\]. It has also been shown that the African Burkitt's lymphoma represents the proliferation of an EBV-genome carrying clone, in the vast majority of the cases \[4\]. The relatively few non-African BL cases so far studied were EBV-DNA negative \[5-7\],a lthough occasional EBV-positive cases bave now been found \[8, 9\]. Serological evidence on a larger number of cases also failed to show the uniform anti-EBV positiv,-'ty, and rite approximately tenfold elevation of mean titers characteristic for the African BL. In the African BL material examined, two cases were found that lacked detectable EBV-DNA and EBNA although the patients had high serum anti EBV titers \[1, 2\]. The permanent lymphoid cell lines that were established from these tumors were also EBV-negative, but they could be converted to Accepted 22 November 1976 *This work was supported by contract No. 1-CP 3-3342 from the Virus Cancer Program of the National Cancer Institute, United States Public Health Service.",
year = "1977",
month = jul,
doi = "10.1016/0014-2964(77)90055-X",
language = "English",
volume = "13",
pages = "693--698",
journal = "European Journal of Cancer (1965)",
issn = "0014-2964",
publisher = "Pergamon Press Ltd.",
number = "7",
}