A case of alprazolam, but not lorazepam, inducing manic symptoms

W. K. Goodman, D. S. Charney

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A patient developed manic symptoms during treatment with alprazolam. These symptoms remitted upon discontinuation of treatment, but reemerged during a second trial with alprazolam. Subsequent administration of an equivalent dosage of lorazepam did not induce manic symptoms. The clinical and theoretical implications of these findings are discussed in relation to the possible mechanisms of action of alprazolam, a novel benzodiazepine.

Original languageEnglish
Pages (from-to)117-118
Number of pages2
JournalJournal of Clinical Psychiatry
Issue number3
StatePublished - 1987
Externally publishedYes


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