A case-control study of alzheimer’s disease in China

G. Li; Y. C. Shen; Y. Li; C. H. Chen; Y. W. Zhau; J. M. Silverman

doi:10.1212/wnl.42.8.1481

A case-control study of alzheimer’s disease in China

G. Li
, Y. C. Shen
, Y. Li
, C. H. Chen
, Y. W. Zhau
, J. M. Silverman

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age and sex–matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first–degree relatives, family history of psychotic disorders in first–degree relatives, and left–handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.

Original language	English
Pages (from-to)	1481-1488
Number of pages	8
Journal	Neurology
Volume	42
Issue number	8
DOIs	https://doi.org/10.1212/wnl.42.8.1481
State	Published - Aug 1992

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title = "A case-control study of alzheimer{\textquoteright}s disease in China",

abstract = "We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age and sex–matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first–degree relatives, family history of psychotic disorders in first–degree relatives, and left–handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.",

author = "G. Li and Shen, \{Y. C.\} and Y. Li and Chen, \{C. H.\} and Zhau, \{Y. W.\} and Silverman, \{J. M.\}",

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AU - Li, G.

AU - Shen, Y. C.

AU - Li, Y.

AU - Chen, C. H.

AU - Zhau, Y. W.

AU - Silverman, J. M.

PY - 1992/8

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N2 - We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age and sex–matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first–degree relatives, family history of psychotic disorders in first–degree relatives, and left–handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.

AB - We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age and sex–matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first–degree relatives, family history of psychotic disorders in first–degree relatives, and left–handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.

UR - https://www.scopus.com/pages/publications/0026778840

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SP - 1481

EP - 1488

JO - Neurology

JF - Neurology

IS - 8

ER -

A case-control study of alzheimer’s disease in China

Abstract

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