A blueprint for human whole-cell modeling

Balázs Szigeti, Yosef D. Roth, John A.P. Sekar, Arthur P. Goldberg, Saahith C. Pochiraju, Jonathan R. Karr

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalCurrent Opinion in Systems Biology
StatePublished - 1 Feb 2018


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