TY - JOUR
T1 - A blueprint for human whole-cell modeling
AU - Szigeti, Balázs
AU - Roth, Yosef D.
AU - Sekar, John A.P.
AU - Goldberg, Arthur P.
AU - Pochiraju, Saahith C.
AU - Karr, Jonathan R.
N1 - Funding Information:
We thank Yin Hoon Chew and Nicolas Le Novére for critical feedback on the manuscript and we thank Michael Hucka, Derek Macklin, and Pedro Mendes for critical feedback on the survey questions. This work was supported by a National Institute of Health MIRA award [grant number 1 R35 GM 119771-01]; a National Science Foundation INSPIRE award [grant number 1649014]; and the National Science Foundation/ERASyn- Bio [grant numbers 1548123, 335672]
Funding Information:
We thank Yin Hoon Chew and Nicolas Le Novére for critical feedback on the manuscript and we thank Michael Hucka, Derek Macklin, and Pedro Mendes for critical feedback on the survey questions. This work was supported by a National Institute of Health MIRA award [grant number 1 R35 GM 119771-01 ]; a National Science Foundation INSPIRE award [grant number 1649014 ]; and the National Science Foundation/ERASynBio [grant numbers 1548123 , 335672 ].
Publisher Copyright:
© 2017 Elsevier Ltd. All rights reserved.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.
AB - Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.
UR - http://www.scopus.com/inward/record.url?scp=85038810870&partnerID=8YFLogxK
U2 - 10.1016/j.coisb.2017.10.005
DO - 10.1016/j.coisb.2017.10.005
M3 - Review article
AN - SCOPUS:85038810870
SN - 2452-3100
VL - 7
SP - 8
EP - 15
JO - Current Opinion in Systems Biology
JF - Current Opinion in Systems Biology
ER -